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GW23-e2083
SILDENAFIL PLUS UNDECANOATE AND SILDENAFIL ALONE IN THE TREATMENT OF TYPE 2 DIABETIC PATIENTS WITH ERECTILE DYSFUNCTION
  1. Erhong Zhang1,
  2. Bin Zhang1,
  3. Jun Chen1,
  4. Zhijun Zang1,
  5. Tao Qi1,
  6. Bin Zhang2
  1. 1the Third Affiliated Hospital of Sun Yat-Sen University
  2. 2The Third Affiliated Hospital of Sun Yat-Sen University

    Abstract

    Objectives To compare the efficacy and safety of Sildenafil plus Undecanoate (Andriol) with those of Sildenafil alone in the treatment of Type 2 diabetic patients with erectile dysfunction (ED).

    Methods Forty patients with Type 2 diabetic ED were randomly divided into two Groups, aged 32∼55 years. These patients in two groups were age-matched. Group A received 50 mg Sildenafil 30 min before planned sexual activity for 12 weeks, and Group B were given 40 mg Andriol after breakfast and supper daily and give 50 mg Sildenafil 30 min before sexual activity for 12 weeks. Before and after the treatment, IIEF-5 score, the intercourse satisfaction, and the drug- related side effects were evaluated.

    Results Erectile function of both groups was obviously improved after treatment than that before treatment. IIEF-5 scores were (11.3±2.1), (16.2±2.4) respectively at baseline and post-treatment in Group A, and (10.8±1.9), (18.4±2.2) in Group B. The improvement is more significant in Group B. In addition, Group B subjects were more satisfied with treatment and had a higher intercourse success rate. As for the side effects, there was no significant difference in two groups. The majority of side events were mild, the most commonly reported treatment-related events were dizziness and tinnitus.

    Conclusions Undecanoate combined with Sildenafil maybe more effective to improve the erectile function than Sildenafil alone in Type 2 diabetic patients with erectile dysfunction.

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