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GW23-e1854
HIGH SENSITIVITY C-REACTIVE PROTEIN AND THE RISK OF STENT THROMBOSIS AND CARDIOVASCULAR EVENTS
  1. Hu Bin,
  2. Zhou Yujie
  1. Beijing Anzhen Hospital Affiliated to Capital Medical University

    Abstract

    Objectives To investigate in a follow-up study whether high-sensitivity C-reactive protein (hs-CRP) predicts coronary heart disease (CHD) events and stent thrombosis in subjects undergone drug-eluting stent implantation.

    Methods We evaluated 3691 patients treated with drug-eluting stents who had a baseline CRP measurement. The primary outcome was stent thrombosis; secondary outcomes were death, myocardial infarction (MI), death or MI, and target vessel revascularisation.

    Results During follow-up (median, 2 years), 26 patients had definite or probable stent thrombosis, 146 patients died, 239 had an MI, and 206 underwent target vessel revascularisation. In multivariable Cox proportional-hazards models, elevated levels of hs-CRP were significantly associated with increased risk of stent thrombosis. Elevated hs-CRP levels also significantly predicted the risks of death, MI, and death or MI, but not target vessel revascularisation.

    Conclusions Elevated hs-CRP levels were significantly associated with increased risks of stent thrombosis, death, and MI in patients receiving drug-eluting stents, suggesting the usefulness of inflammatory risk assessment with CRP.

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