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GW23-e1590
EFFECTS OF AUTOLOGOUS BONE MARROW MONONUCLEAR CELLS TRANSPLANTATION VIA CORONARY ARTERY IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION ASSESSED BY MRI
  1. Minjie Lu,
  2. Lei Song,
  3. Shiliang Jiang,
  4. Yuejing Yang,
  5. Yan Zhang,
  6. Gang Yin,
  7. Shihua Zhao
  1. Fuwai Hospital & Cardiovascular Institute, Chinese Academy of Medical Sciences & Tsinghua University, Peking Union Medical College, National Center for Cardiovascular Diseases

    Abstract

    Objectives The aim of this study was to use an ‘one-stop’ non-invasive imaging examination-MRI to evaluate the feasibility and safety of aBM-MNC transplantation in patients with acute myocardial infarction (AMI) undergoing percutaneous coronary intervention.

    Methods We did a randomised, double-blind, placebo-controlled study in 60 patients (male=43, female=17, age 52.18±4.98 years) with AMI. The patients were randomly divided into 2 groups (group A: PCI+ aBM-MNC, group B: PCI only). Preoperative global left ventricular functions and scar tissue were measured by MRI. The therapeutic effects were assessed by MRI 6-month after aBM-MNC transplantation.

    Results ALL the patients were treated without major complications. There is no evidence of new ventricular arrhythmia or neoplasia. The LVEF was improved 28.5% in group A, while 18.4% in group B (p<0.01), LVEDV/m2 and LVESV/m2 were decreased by 21.15±3.96 ml/m2 and 27.14±4.48, respectively, which were significantly different from that in group B (5.85±6.18 ml (p=0.08) and 9.18±4.84 (p=0.04)). The cardiac output (CO), cardiac index (CI) and cardiac mass (CM) didn't show significant difference between the two groups. Compared with group B, aBM-MNC group was associated with no significant reduction in myocardial infarct size (15.3% vs 12.7%, p=0.51).

    Conclusions Comprehensive in vivo CMR reveals reversed remodelling and improved systolic function and scar characteristics after aBM-MNC transplantation. PCI+aBM-MNC transplantation can lead to comparable improvements of left ventricle in acute myocardial infraction.

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