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GW23-e0661
THE EFFECT OF JIAWEI BUYANG HUANWU DECOCTION ON THE NO SYSTEM AFTER ILIAC ARTERY BALLOON INJURED IN RABBITS
  1. Zhou Bin1,
  2. Liu Yong1,
  3. Zhang Jun2,
  4. Hao Bao-shun1,
  5. Liu Ding-hui1,
  6. Wang Min1,
  7. Wu Lin1,
  8. Chen Lin1,
  9. Liu Jin-lai1,
  10. Wu Wei-kang3,
  11. Qian Xiao-xian4
  1. 1Department of Cardiology, The Third Affiliated Hospital, Sun Yat–sen University
  2. 2Department of Nephrology, The Third Affiliated Hospital, Sun Yat–sen University
  3. 3Institute for Integrated Traditional Chinese and Western Medicine, The Third Affiliated Hospital, Sun Yat–sen University
  4. 4Department of Cardiology, Institute for Integrated Traditional Chinese and Western Medicine, The Third Affiliated Hospital, Sun Yat–sen University

    Abstract

    Objectives To investigate the effect of Jiawei Buyang Huanwu Decoction in preventing vascular restenosis and on the nitric oxide (NO) system after rabbit iliac artery balloon injury.

    Methods 24 male New Zealand albino rabbits were equally randomised into control group, model group and drug group. The iliac arteries of the rabbits in the latter two groups were subjected to balloon injury. Four weeks later, serum NO synthases (NOS) activity and endothelial nitric oxide synthase (eNOS) level was assayed, Endothelial hyperplasia, eNOS Protein and mRNA expression were observed in injured iliac artery.

    Results Optical microscope revealed narrowed vascular lumen, thicken intima and numerous arteriosclerotic plaques in the model group compared with the control group, whereas the vascular lumen and intima thickness remained basically normal in drug group. The serum NO level and total NOS activity were lower in model group than that of control group and drug group, while there is no difference between the latter two. Immunohistochemistry and RT-PCR results showed that eNOS protein and mRNA expression was stronger in rabbit iliac artery of control group and drug group than that in model group.

    Conclusions Jiawei BHD can lessen intimal hyperplasia and vascular stenosis in iliac artery injury rabbits, this effect is possibly related with that Jiawei BHD activated the NO system.

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