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Cardiovascular disease clinical research
Acute coronary syndrome
GW23-e1096
THE RELEVANCE AMONG SERUM CRP LEVEL, CRP GENE C+1444T POLYMORPHISM AND THE RISK WITH ACUTE MYOCARDIAL INFARCTION
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  1. He Guo-Ping⇓,
  2. Yang Hai-Tao,
  3. Qi Chuan-Ping,
  4. Xu Lian-Hong,
  5. Qian Yi-Chao,
  6. He Guo-Ping
  1. Affiliated Wujin Hospital of Jiangsu University, Changzhou 213002, China

    Abstract

    Objectives To investigate the relationship between serum CRP level, CRP gene C+1444T polymorphism and the risk with AMI from Sunan Chinese population.

    Methods The serum CRP level was measured by enzyme linked immunosorbent assay (ELISA) and the CRP gene C+1444T polymorphism was genotyped by Polymerase reaction restriction-fragment length polymorphism (PCR-RFLP) between 227 patients with AMI (AMI group) and 161 control subjects.

    Results 1. No differences were found in genotype distribution between AMI group and controls (CC 82.38%, CT 17.62%, TT 0 vs 86.96%, 13.04%, 0) (p>0.05).

    2. The serum CRP level in AMI group was significantly higher than controls (p<0.01).

    3. There were no differences in the serum levels between any genotypes of the CRP gene C+1444T (p<0.05).

    Conclusions The CRP gene C+1444T polymorphism was not associated with increased risk of AMI, and it did not yet effect the serum levels in Chinese Han population of Sunan region.

    https://doi.org/10.1136/heartjnl-2012-302920k.20

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