Objectives To investigate the relationship between serum CRP level, CRP gene C+1444T polymorphism and the risk with AMI from Sunan Chinese population.
Methods The serum CRP level was measured by enzyme linked immunosorbent assay (ELISA) and the CRP gene C+1444T polymorphism was genotyped by Polymerase reaction restriction-fragment length polymorphism (PCR-RFLP) between 227 patients with AMI (AMI group) and 161 control subjects.
Results 1. No differences were found in genotype distribution between AMI group and controls (CC 82.38%, CT 17.62%, TT 0 vs 86.96%, 13.04%, 0) (p>0.05).
2. The serum CRP level in AMI group was significantly higher than controls (p<0.01).
3. There were no differences in the serum levels between any genotypes of the CRP gene C+1444T (p<0.05).
Conclusions The CRP gene C+1444T polymorphism was not associated with increased risk of AMI, and it did not yet effect the serum levels in Chinese Han population of Sunan region.