Article Text

PDF

GW23-e2389
EFFECT OF VALSARTAN ON EXTRACELLULAR MATRIX REMODELLING IN RATS WITH HEART FAILURE AFTER MYOCARDIAL INFARCTION
  1. Zhao Juan,
  2. Tian Ye
  1. The First Clinical Hospital of Harbin Medical University

    Abstract

    Objectives To investigate the effect of Valsartan on the change of Disintegrin metalloproteinases (ADAMs10,17) expressions in the heart failure (HF) process after myocardial infarction (MI).

    Methods Based on UCG (LVEF<45%) results, the successfully MI-operated Wistar rats were divided into three groups: HF group, placebo group and Val group, which were given Valsartan by gavage. After 16 weeks, all rats were assessed by hemodynamic evaluation and serum TNF-α from LV was measured by ELISA (R & D, USA). In addition, their left ventricular (LV) muscle samples were extracted from the ischaemic segments, and then the ADAMs 10,17 expression were measured by immunoblotting.

    Results In this study, heart failure (LVdp/dtmax, LVdp/dtmin and LVSP) was significantly elevated in Val group than the others (p=0.006, p=0.015, p=0.003), and the LVEDP level was decreased (p=0.002). At the same time, the TNF-a level in Val group was lower than HF groups (p=0.023). The ADAM17 and TNF-R1 expressions in Val group was lower compared with those in HF group (p=0.011, p=0.022). However, ADAM10 expression is unchangeable in the four groups.

    Conclusions Valsartan may reduce the ADAM17 and TNF-R1 expression in the ischaemic zone of myocardium, decrease the TNF-a concentration in LV so as to inhibit cardiac remodelling and improve the heart function after MI.

    Statistics from Altmetric.com

    Request permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.