Article Text

PDF

GW23-e0726
GENOMIC CHARACTERISTICS OF ADHESION MOLECULES IN PATIENTS WITH SYMPTOMATIC PULMONARY EMBOLISM
  1. Yuan Xie1,
  2. Zhu Gong1,
  3. Qianglin Duan1,
  4. Qiang Wang1,
  5. Haoming Song1,
  6. Aibin Liang2,
  7. Hao Wang1,
  8. Wenwen Yan1,
  9. Lemin Wang1
  1. 1Department of Cardiology, Tongji Hospital, School of Medicine, Tongji University
  2. 2Department of Hematology, Tongji Hospital, School of Medicine, Tongji University

    Abstract

    Objectives To find out the differences of cell adhesion molecule-related mRNAs expression between symptomatic pulmonary embolism (PE) and control group, and to investigate the interactions among activated leukocytes, platelets and endothelial cells.

    Methods Whole human gene chip was applied to detect cell adhesion molecule-related mRNAs expression in symptomatic PE and control group, and then statistical analysis was performed.

    Results In patients with PE, the expression of most mRNAs related to integrins which located in leukocytes and platelets was significantly up-regulated; the expression of mRNAs related to L-selectin and P-selectin glycoprotein ligand was significantly up-regulated, while the expression of mRNA related to E-selectin was significantly down-regulated; the expression of mRNAs related to classic cadherins and protocadherins tended to down-regulate as a whole, and the expression of mRNA related to vascular endothelial cell cadherin was significantly down-regulated; the expression of mRNAs related to the immunoglobulin superfamily had no obvious difference between the two groups.

    Conclusions The results demonstrated that, in symptomatic PE patients, the adhesion of leukocytes and platelets were enhanced; the activation of endothelial cells was obviously weakened; the adherens junctions among endothelial cells were weakened, with the endothelium becoming more permeable.

    Statistics from Altmetric.com

    Request permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.