Objectives To observe and evaluate the clinical efficacy and safety of clopidogrel on acute non-ST elevation myocardial infarction (NSTEMI) .
Methods 30 patients with acute NSTEMI in the control group were treated with Low Molecular Heparin, Aspirin and other anti-anginal drugs. Another 30 patients with acute NSTEMI were treated with Low Molecular Heparin, Aspirin combined with Clopidogrel, which the initial dose is 300 mg and followed 75 mg/d for 2 weeks in treatment group.
Results Compared with the control group, the recurrence rate of cardiac angina was significantly reduced in the treatment group (p<0.05). Clinical symptoms and the depression of ST segment in electrocardiograph were improved apparently (p<0.05), and there was little influence on the index of blood clotting (p>0.05) .
Conclusions The treatment of clopidogrel combined with the traditional anticoagulant drugs would be more effective and safe to NSTEMI.