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GW23-e2697
THE EFFECTS OF VELVET ANTLER OF DEER ON CARDIAC FUNCTIONS OF RATS WITH HEART FAILURE FOLLOWING MYOCARDIAL INFARCTION
  1. Ming-Jing Shao1,
  2. Shuo-Ren Wang2,
  3. Ming-Jing Zhao2,
  4. Xi-Ling Lv2,
  5. Hao Xu1,
  6. Lin Li1,
  7. Huan Gu1,
  8. Jiu-Liang Zhang1,
  9. Ge Li1,
  10. Xiang-Ning Cui1,
  11. Li Huang1,
  12. Ming-Jing Shao1
  1. 1National Integrated Traditional and Western Medicine Center for Cardiovascular Disease, China-Japan Friendship Hospital, Beijing, China
  2. 2Laboratory of Traditional Chinese Internal Medicine, Dongzhimen Hospital affiliated to Beijing University of Chinese Medicine, Beijing, China

    Abstract

    Objectives Velvet antler of deer (VAD) is a commonly-used kidney-Yang supplementing traditional Chinese medication. According to the heart-kidney-related theory, heart Yang originates in kidney Yang and therefore heart failure due to heart Yang deficiency can be treated by tonifying kidney Yang. In this study, we investigated therapeutic effects of VAD on cardiac functions in rats with heart failure following myocardial infarction. Forty-eight male Wista rats were subjected either to left coronary artery ligation (N=36) or to sham operation (N=12). One week after the surgery, rats with heart failure received daily treatment of double-distilled water (the HF group), captopril (the HF+CAP group) or velvet antler of deer (the HF+VAD group) by gavage for consecutively 4 weeks, while sham-operated animals (the SHAM group) were administered double-distilled water once daily for 4 weeks. Ultrasonic echocardiography was adopted to examine cardiac structural and functional parameters and serum Brain natriuretic peptide (BNP) concentration was measured using radioimmunoassay. We found that VAD partially reversed changes in cardiac functional parameters and serum BNP levels in rats with heart failure. These results provide evidence for the heart-kidney-related theory of traditional Chinese medicine and demonstrate that heart failure due to heart Yang deficiency can be treated by strengthening kidney Yang. Therefore, VAD might be a potentially alternative and complementary medicine used in the treatment of heart failure.

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