Objectives The current study is to see whether 3D speckle tracking is useful when evaluating heart functions in patients with mitral regurgitation.
Methods Forty-five consecutive asymptomatic patients with severe mitral regurgitation due to flail leaflets and 30 gender- and age-matched healthy participants were enrolled in the study.
Routine echocardiography, Colour Doppler and 3D echocardiography were performed on all subjects (Philip IE33, s5-1, X3-1). Biplane Simpson's method was used to obtain left ventricular ejection fraction (LVEF). Vena contracta (VC) and proximal isovelocity surface area (PISA) methods were both used to grade the mitral regurgitation. 3D data were analysed off-line by TOM-TEC 4D LV analysis station to get Systolic Peak Strain(S) of basal (Sb), middle(Sm) and apical segments (Sa) and their time to peak (Tb, Tm and Ta). All the parameters are indexed by body surface area (BSA) or cardiac cycle.
Results 1. Indexed Time to Peak 3D strain is delayed in Patient Group (MR vs Con: Tb: 0.40±0.05% vs 0.37±0.03%;Tm: 0.42±0.06% vs 0.39±0.04%; Ta: 0.40±0.05% vs 0.36±0.05%, all p<0.05).
2. Systolic peak of 3D strain increases in Patient Group (MR vs Con: Sb: 18.61±4.01% vs 15.03±12.66%, p>0.05; Sm:22.86±5.16% vs 16.94±14.12%, p<0.05; Sa: 23.45±7.24% vs 16.95±15.21%, p<0.05).
Conclusions Peak 3D strain can be influenced by mitral regurgitation and thus is unable to evaluate its left ventricular function accurately. However, Time to Peak 3D strain is less volume-dependent and may be helpful in follow-up of mitral regurgitation patients.