Objectives To investigate the clinical value of wave intensity (WI) in assessing left ventricular function of patients with early type 2 diabetes mellitus and combined with hypertension.
Methods Twenty-one patients with type 2 diabetes mellitus (T2DM) and 25 T2DM patients combined with essential hypertension group (T2DM+EH), all of left ventricular ejection fraction (LVEF) in two groups of patients were 350%, were enrolled in this study, and 25 healthy volunteers were taken as control group. Each patient underwent echocardiographic and WI exam. The indexes of conventional echocardiography and WI including W1, W2, R-W1 and W1-W2 of right common carotid artery (CCA) in three groups were measured and compared.
Results No statistically significant difference was found for LVEF in three groups. Prorsad expanded wave peak W2 in T2DM group increased more obviously than that in the control group (3.5308±1.0980 mm Hg m/s3 vs 2.1240±0.6870 mm Hg m/s3, p<0.01). Prorsad compressed wave peak Wl in T2DM group was higher than that in control group (13.3769±7.2140 mm Hg m/s3 vs 9.0600±3.3257 mm Hg m/s3, p<0.05). Time of W1-W2 in T2DM group was significantly shortened compared with control group (234.8±29.1 ms vs 276.1±22.8 ms, p<0.01). Compared with the control group, Wl in T2DM+EH group was more obviously higher (20.0957±10.5663 mm Hg m/s3 vs 9.0600±3.3257 mm Hg m/s3, p<0.01), and W2 increased significantly (2.8522±1.6223 mm Hg m/s3 vs 2.1240±0.6870 mm Hg m/s3, p<0.05). Wl in T2DM+EH group was higher than that in T2DM group (p<0.05). W2 in T2DM+EH group reduced than that in T2DM group, but no statistically significant difference was found between the two groups.
Conclusions WI can be used as new method to evaluate left ventricular dysfunction in patients with early type 2 diabetes mellitus and T2DM combined with EH.