Article Text


  1. VV Gafarov,
  2. DO Panov,
  3. EA Gromova,
  4. I.V. Gagulin,
  5. VV Gafarov
  1. Collaborative Laboratory of Epidemiology Cardiovascular Diseases Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk


    Objectives To study the influence of sleep disturbances (SD) on relative risk of an arterial hypertension (AH) incidence in women aged of 25–64 years during 16 years of follow up in Novosibirsk.

    Methods Within the WHO “MONICA-psychosocial” programme random representative sample of women aged 25–64 years who were residents of one district in Novosibirsk, were surveyed in 1994. Questionnaire ‘Awareness and attitude towards the health’ was used to estimate quality of sleep. From 1995 to 2010 women were followed for 16 years for the incidence of AH. AH was defined as 140/90 mm Hg or higher and/or reception of antihypertensive drugs. Cox proportional regression model was used for an estimation of relative risk (HR) of AH. Chi-square (χ2) was used for assessment of statistical significance between groups. Women having AH at the baseline were not included in the analysis.

    Results AH was developed in 33.4% women during 16 years of follow up. SD in studied cohort were revealed in 65.3% of women. HR of AH in women with SD during the first 5 years of study was more than in 4 time higher compared women with good self-estimation of sleep (HR=4.35, 95.0% CI 1.29 to 14,59; p<0.05). With regard to age categories, there was a tendency of increasing AH risk in 35–44 and 55–64 years age groups. During 10 years of study women with SD had 2.7 times higher risk of AH (HR=2.69, 95.0% CI 1.01 to 7.15; p<0.05), and there was also a tendencies of higher risk in all age categories with the exception of 25–34 years. We did not have significant risk of AH during 16 years of follow up in women with SD (HR=1.05, 95% CI 0.74 to 1.48; p>0.05) but there was the tendency of higher risk of AH in older age groups.

    Our findings show AH incidence rates were significantly higher in divorced women with SD compared those who were married with good sleep (χ2=4.025 df=1 p<0,05). There was tendency of increasing AH rates in women with higher school education having SD compared those with higher (university) education (χ2=3.301 df=1 p=0,069) and uncompleted higher or college education (χ2=2.793 df=1 p=0,095) having good sleep. With regard to occupational status, the rate of AH incidence was higher in middle managers (χ2=4.340 df=1 p<0,05), managers (χ2=9.190 df=1 p<0,01), moderate manual workers (χ2=4.074 df=1 p<0,05) and easy manual worker (χ2=7.226 df=1 p<0,01) having SD, compared women moderate manual work having good sleep. There was higher rate of AH in managers (χ2=7.217 df=1 p<0.01) and easy manual worker (χ2=5.133 df=1 p<0.05) with SD compared engineers having good sleep.

    Conclusions There is high prevalence of SD in Russian female population aged 25–64. During 16 years of follow up women with SD have significantly higher risk of AH, especially on first 5 years of study. SD associated with higher rate of AH incidence in divorced women occupied in class of managers and manual work class.

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