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GW23-e2237
PREVALENCE OF HYPERHOMOCYSTEINEMIA AND ITS MAJOR DETERMINANTS IN RURAL CHINESE HYPERTENSIVE PATIENTS
  1. Lixiaoying Wangyu
  1. PLA General Hospital

    Abstract

    Objectives To investigate the prevalence of hyperhomocysteinemia and its major determinants in rural Chinese hypertensive patients.

    Methods A community-based cross-sectional study.

    Results A high percentage of the study subjects had hyperhomocysteinemia (51.7%) with men (65.8%) higher than women (42.8%). The frequency of the CT and TT genotypes of the MTHFR C677T polymorphism were 50.2%, and 26.4%, respectively. In multivariate logistic analysis, there was an increased risk of hyperhomocysteinemia in subjects with older age (55–64 years: OR 1.69, 95% CI 1.44 to 2.00; 65 to 75 years: 3.01 2.70 to 3.35); MTHFR C677T polymorphism (in men: CT 1.44, 1.25–1.65, TT: 4.96, 4.14–5.94; in women: CT 1.20, 1.07–1.35, TT 3.80, 3.33–4.34); abdominal obesity (1.15, 1.07–1.25); antihypertensive treatment (1.17, 1.08–1.26); and inland residence (1.14, 1.05–1.24). However, a lower risk of hyperhomocysteinemia was associated with physical activity.

    Conclusions We found a high prevalence of hyperhomocysteinemia and TT genotypes of the MTHFR C677T polymorphism in rural Chinese hypertensive patients. Besides controlling for hypertension, interventions should take homocysteine-lowering therapy into consideration, including folic acid supplementation and increased physical activity.

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