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GW23-e2039
IL-21R EXPRESSION ON CD8+T CELLS PROMOTES CD8+T CELL ACTIVATION IN COXSACKIEVIRUS B3 INDUCED MYOCARDITIS
  1. Tengfei Xu1,
  2. Wei Liu2
  1. 1The First Affiliated Hospital of Harbin Medical University
  2. 2The First Affiliated Hospital of Harbin Medical University

    Abstract

    Objectives To evaluate the role of IL-21 in promoting CD8 T cell mediated cardiac injury in myocarditis.

    Methods To evaluate the role of IL-21 in promoting CD8 T cell mediated cardiac injury in myocarditis, C57BL/6 and IL-21RKO mice were infected with CVB3. HE staining was used to evaluate history pathology. Differences between groups were determined by Wilcoxon Ranked Score.

    Results These data demonstrate that IL-21 signalling directly in the CD8 cell population is required for CVB3-induced myocarditis.

    Conclusions This study demonstrates that IL-21 is important in CVB3 immunopathogenicity and that the cytokine effect is mediated exclusively through promotion of CD8 activation and/or survival. IL-21 has been shown to be protective in several viral diseases, but in the previously published studies, the IL-21 effect has been primarily directed toward enhancing elimination of the virus. In contrast, this study demonstrates that IL-21 has no detectable effect on host control of coxsackievirus B3 concentrations in the heart. Although IL-21 has immunomodulatory effects on multiple lymphoid cell subsets, including CD4, CD8, B cells and NK cells, in the CVB3 myocarditis model, IL-21 signalling deficiency selectively in the CD8 T cell population provides the same level of myocarditis protection as observed in IL-21RKO mice lacking IL-21 signal transduction in all cell subpopulations.

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