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Heart 99:1317-1322 doi:10.1136/heartjnl-2013-303592
  • Global burden of cardiovascular disease

Recent advances in the epidemiology, pathogenesis and prognosis of acute heart failure and cardiomyopathy in Africa

  1. Bongani M Mayosi1
  1. 1Hatter Institute for Cardiovascular Research in Africa and Institute of Infectious Diseases and Molecular Medicine, Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa
  2. 2Soweto Cardiovascular Research Unit, University of the Witwatersrand, Johannesburg, South Africa
  1. Correspondence to Professor Bongani M Mayosi, Department of Medicine, Old Groote Schuur Hospital, Anzio Road, Observatory, Cape Town 7925, South Africa; bongani.mayosi{at}uct.ac.za
  • Received 3 January 2013
  • Revised 4 March 2013
  • Accepted 5 March 2013
  • Published Online First 16 May 2013

Abstract

This review addresses recent advances in the epidemiology, pathogenesis and prognosis of acute heart failure and cardiomyopathy based on research conducted in Africa. We searched Medline/PubMed for publications on acute decompensated heart failure and cardiomyopathy in Africa for the past 5 years (ie, 1 January 2008 to 31 December 2012). This was supplemented with personal communications with colleagues from Africa working in the field. A large prospective registry has shown that acute decompensated heart failure is caused by hypertension, cardiomyopathy and rheumatic heart disease in 90% of cases, a pattern that is in contrast with the dominance of coronary artery disease in North America and Europe. Furthermore, acute heart failure is a disease of the young with a mean age of 52 years, occurs equally in men and women, and is associated with high mortality at 6 months (∼18%), which is, however, similar to that observed in non-African heart failure registries, suggesting that heart failure has a dire prognosis globally, regardless of aetiology. The molecular genetics of dilated cardiomyopathy, hypertrophic cardiomyopathy and arrhythmogenic right ventricular cardiomyopathy in Africans is consistent with observations elsewhere in the world; the unique founder effects in the Afrikaner provide an opportunity for the study of genotype–phenotype correlations in large numbers of individuals with cardiomyopathy due to the same mutation. Advances in the understanding of the molecular mechanisms of peripartum cardiomyopathy have led to promising clinical trials of bromocriptine in the treatment of peripartum heart failure. The key challenges of management of heart failure are the urgent need to increase the use of proven treatments by physicians, and the control of hypertension in primary care and at the population level.