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Recently Reinstadler et al reported on a study in n=54 patients diagnosed with STEMI who underwent copeptin sampling 2 (1–3) days after the index event and Cardiac Magnetic Resonance (CMR) on the same day. A follow-up CMR study was done after 4 months in n=47 patients.
The authors found a strong and significant correlation between day 2 copeptin and ejection fraction, end systolic volume, stroke volume and per cent infarct mass. Additionally, using optimised cutoffs, adverse remodelling could be excluded by the combination of copeptin with NT-proBNP.1
Copeptin is a stable glycopeptide comprising the C-terminal part of the AVP arginine-vasopressine prohormone.2 Copeptin is known to be released by the hypophysis early upon the trigger of arterial underfilling, for example, in the case of immediate …