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Correspondence
Patent foramen ovale closure and brain ischaemic lesions
  1. Enrico Ammirati1,
  2. Giancarlo Comi2,
  3. Paolo G Camici1
  1. 1Cardiovascular Department, Vita-Salute University and San Raffaele Scientific Institute, Milan, Italy
  2. 2Department of Neurology, Vita-Salute University and San Raffaele Scientific Institute, Milan, Italy
  1. Correspondence to Professor Paolo G Camici, Cardiovascular Department, Vita-Salute University and San Raffaele Scientific Institute, Milan, Italy; camici.paolo{at}hsr.it

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To the Editor The recently published meta-analysis by Wolfrum et al assessed the ability of percutaneous closure of patent foramen ovale (PFO) to reduce the incidence of recurrent stroke based on three randomised controlled clinical trials (RCT). This analysis did not demonstrate a superiority of the closure of PFO …

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