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Correspondence
  1. Pascal Meier1,2,
  2. Mathias Wolfrum3,
  3. Georg M Froehlich1,
  4. Leanne K Casaubon,
  5. Alexandra J Lansky2
  1. 1 Yale—UCL Cardiovascular Research Program, The Heart Hospital, University College London Hospitals UCLH, London, UK
  2. 2 Division of Cardiology, Yale Medical School, New Haven, Connecticut, USA
  3. 3 Division of Internal Medicine, Spital Zollikerberg, Zollikerberg, Switzerland
  4. 4 Division of Neurology, Stroke Program, Toronto Western Hospital, Toronto, Canada
  1. Correspondence to Dr Pascal Meier, Yale—UCL Cardiovascular Research Program, The Heart Hospital, University College London Hospitals, UCLH16-18 Westmoreland Street, London W1G 8PH, UK; pascalmeier74{at}gmail.com

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The Authors' reply We thank Dr Ammirati and his colleagues for their very valuable comments1 on our paper.2 We agree with their interpretation, the low incidence of non-fatal strokes in the medical arm (<1% per annum) makes it very difficult to demonstrate a significant reduction in events with any intervention. This is even more the case for invasive interventions which are of course associated with a periprocedural complication …

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