Article Text


Original article
Fatal venous thromboembolism associated with hospital admission: a cohort study to assess the impact of a national risk assessment target
  1. Will Lester1,2,
  2. Nick Freemantle1,3,
  3. Irena Begaj1,
  4. Daniel Ray1,
  5. John Wood3,
  6. Domenico Pagano1,2
  1. 1Quality and Outcomes Research Unit, University Hospital Birmingham, Birmingham, UK
  2. 2School of Clinical and Experimental Medicine, University of Birmingham, Birmingham, UK
  3. 3Department of Primary Care & Population Health, University College London, London, UK
  1. Correspondence to Professor Domenico Pagano, Department of Cardiothoracic Surgery, University Hospital Birmingham, Queen Elizabeth Hospital, Edgbaston, Birmingham B15 2TH, UK; domenicopagano{at}


Objectives In 2010, the Department of Health in England introduced an incentivised national target for National Health Service (NHS) hospitals aiming to increase the number of patients assessed for the risk of developing venous thromboembolism (VTE) associated with hospital admission. We assessed the impact of this initiative on VTE mortality and subsequent readmission with non-fatal VTE.

Design Observational cohort study.

Patients All patients admitted to NHS hospitals in England between July 2010 and March 2012.

Interventions An NHS hospital which assessed at least 90% of patient admissions achieved the quality standard.

Main outcome measures The principal outcome measured was death from VTE up till 90 days after hospital discharge using linked Office of National Statistics and Hospital Episode Statistics data.

Results In the principal analyses of patients admitted to hospital for more than 3 days, there was a statistically significant reduction in VTE deaths in hospitals achieving 90% VTE risk assessment: relative risk (RR) 0.85 (95% CI 0.75 to 0.96; p=0.011) for VTE as the primary cause of death. In supportive analyses of postdischarge deaths after index admissions of up to 3 days, there was also a reduction in fatal VTE RR 0.61 (0.48 to 0.79; p=0.0002). This effect was seen for both surgical and non-surgical patients. No effect was seen in day case admissions. There was no change in non-fatal VTE readmissions up to 90 days after discharge.

Conclusions A national quality initiative to increase the number of hospitalised patients assessed for risk of VTE has resulted in a reduction in VTE mortality.


Statistics from


Hospital associated venous thromboembolism (VTE) is an important and potentially preventable cause of death and disability. In the Million Women Study cohort,1 the relative risk (RR) of VTE increased more than a 100-fold after hospital admissions for surgical procedures and persisted up to 90 days from the admission; thus, many deaths are expected to occur after discharge from hospital and any VTE event within 90 days may be associated with hospital admission. Deaths from VTE are often sudden or are misdiagnosed premortem and prevention is a key strategy.2 Appropriate use of thromboprophylaxis was described as the ‘number one patient safety practice’ for US hospitals.3 In 2010, the Department of Health in England introduced a national quality initiative (commissioning for quality innovation; CQUIN)4 which imposed financial penalties for hospitals failing to perform VTE risk assessment in at least 90% of their patients using a defined risk assessment tool.5 In conjunction with national guidelines and quality standards produced by the National Institute for Health and Care Excellence, it was expected that patients identified with risk factors for VTE would receive appropriate interventions to reduce their risk (including patient information and mechanical and/or pharmacological thromboprophylaxis). However, this national policy has generated some controversy, particularly in relation to medical patients.6 ,7

The true magnitude of the problem associated with hospital acquired VTE is not well described empirically, and the effectiveness of strategies to reduce its risks are unknown outside of the context of clinical trials. The aim of this study was to assess the impact of the incentivised policy of risk assessment for VTE on hospital-associated VTE mortality and VTE readmission.


Analysis was based upon a series of monthly observations from each National Health Service (NHS) hospital trust in England, and the association between outcomes and the achievement or otherwise of the VTE risk assessment target in that month. Patients were included in the analysis based on their date of admission. In the principal analyses, we included all patients admitted to hospital for more than 3 days, excluding all deaths occurring before the fourth day from admission and any fatality occurring when Hospital Episode Statistics (HES) coding for the admission contained an International Classification of Diseases (ICD10) VTE code in position one (as this would represent delayed death in a patient admitted with VTE rather than death from VTE occurring during or after the index hospital admission). VTE mortality was described as ‘inhospital’ or ‘postdischarge’ (within 90 days after discharge) and as a total of these two periods (ie, deaths which occurred more than 3 days after admission and within 90 days of discharge).

Summary hospital level data on risk assessment were obtained from monthly submissions to the UNIFY2 database, the database used by the Department of Health in England to monitor performance and trigger incentive payments. Data were extracted on 9 November 2012 by two analysts for quality control. The population studied was all patients admitted to an NHS hospital trust in England (n=163) between July 2010 and March 2012, accessed through HES. The Office of National Statistics data, linked to HES, were used to identify mortality outcomes. Mortality outcomes were considered relevant if an ICD10 VTE code was listed in the first position of the death certificate (‘primary VTE death’), thus where VTE was considered the direct cause of death, or anywhere within the first three positions (‘VTE related death’) where VTE is considered either the direct cause or a contributing cause of death. The ICD10 codes used are those specified by the NHS-Outcome Framework 2013/14:8 I260, I269, I800, I801, I802, I803, I808, I809, I821, I822, I823, I828, I829, O082, O223, O229, O870, O871, O879 and O882.

For events occurring after discharge, we excluded all patients with a HES ICD10 VTE code at any position in the coding of the index admission, thus including only new VTE events. More detailed information on criteria for patient selection is given in online supplementary table S1.

Supportive analyses on the impact of achieving the 90% VTE risk assessment quality standard were performed on patients admitted with less than 4 days of hospital stay, on day case admissions, and by whether or not surgical procedures were undertaken during the index admission (according to ICD10 codes in HES). We also assessed the impact of the intervention on non-fatal hospital readmissions with an ICD10 VTE code at position one or two, thus where VTE was the primary or major contributing cause of the readmission. Finally, we assessed the extent to which our results were sensitive to the 90% risk assessment threshold imposed by the Department of Health (DH) by analysing the relationship between the loge proportion of patients’ risk assessed by trust each month against VTE outcomes. Two informatics experts extracted all data independently, and the resulting data sets were compared to ensure consistency.

Statistical methods

We fitted a Poisson mixed effects model to the counts of the events of interest (deaths, readmissions) for patients admitted in each of the 21 months of data for the 163 English NHS hospital trusts, using a log link function and with the loge of the number of admissions during that month as an offset (weighting) variable. We included a classification variable indicating whether or not the hospitals had achieved the benchmark quality standard of at least 90% of admitted patients being assessed for risk of VTE in that month. Because of the structure of the data, some of the information concerning the effect of achieving the quality standard is contained in comparisons between hospitals but this is also potentially confounded by organisational characteristics not directly related to the quality improvement programme, and some is contained in comparisons between months within hospital organisations. To allow for any consequent bias, hospitals were included in the model as random intercept terms. Since hospital organisations tended to maintain the quality standard once they had initially attained it, there is a partial confounding between that and any other (unknown) monotonic time trends, which might vary somewhat between hospitals. To allow efficiently for this in the model, an overall linear fixed effects variable for time was included along with an approximate low rank smoother for time as a random effect within hospitals.9 All analyses were conducted in SAS V.9.2 (SAS Institute, Cary, North Carolina, USA).


Across the 21-month period of the study, on average, hospitals achieved the quality standard (≥90% of admitted patients assessed for VTE risk) 56% of the time. There was a substantial improvement over the time period in the raw VTE screening score supplied by hospital organisations to the Unify2 database. In July 2010 (month 1), the median hospital rate of assessment for VTE risk was 51%, the 25 percentile trust achieved 27% and the 75 percentile trust achieved 71% patients assessed. In March 2012 (the 21st month), the median hospital rate of assessment for VTE risk was 93%, the 25 percentile was 91% and the 75 percentile was 96%. However, there was also significant variation between hospitals. Over the 21-month period, the median proportion of time for which the quality target was achieved was 13/21 months (62%), with lower and upper quartiles of 8/21 months (38%) and 15/21 months (71%), respectively. Further, out of the 163 included hospital trusts, there were nine which never achieved the quality targets, and nine which always achieved them.

Principal analyses: effect of achieving VTE risk assessment target in admissions with >3 days hospital stay

In our principal analyses of patients with more than 3 days inhospital stay, we included data from 4 141 041 admissions, which were associated with 8578 VTE readmissions. Inhospital VTE related mortality occurred in 4334 patients, and primary VTE mortality occurred in 1318 patients. There were 1651 VTE related deaths within 90 days of discharge, of which 895 were primary VTE deaths. Figure 1 shows the distribution of primary VTE deaths over time and whether deaths occurred during admission (red line) or after discharge (blue line).

Figure 1

Histogram to indicate time to fatality with venous thromboembolism code position one of the death certificate after 3 days of hospital admission until 90 days after discharge. The blue bars represent deaths after discharge. Access the article online to view this figure in colour.

In the principal analyses, achieving VTE risk assessment in ≥90% of patients admitted to hospital was associated with a reduction in mortality within 90 days of discharge for primary VTE deaths (RR 0.81; 95% CI 0.67 to 0.97; p=0.026), for total primary VTE deaths both inhospital and within 90 days from discharge (RR 0.85; 0.75 to 0.96; p=0.011) and for total deaths where VTE was in any of the first three positions on the death certificate (RR 0.92; 95% CI 0.85 to 0.99; p=0.033) (figure 2). In contrast, achieving the quality standard had no effect on the rate of non-fatal VTE readmission within 90 days (RR 1.04; 95% CI 0.97 to 1.11; p=0.301). Inhospital mortality for primary VTE deaths (RR 0.86; 95% CI 0.74 to 1.01; p=0.061) or VTE related deaths (RR 0.92; 95% CI 0.84 to 1.00; p=0.057) and VTE related deaths within 90 days of discharge (RR 0.91; 95% CI 0.79 to 1.05; p=0.196) did not reach statistical significance in isolation.

Figure 2

Principal analysis examining the impact of achieving the venous thromboembolism (VTE) risk assessment quality standard on mortality outcomes and non-fatal VTE readmissions for patients admitted to hospital >3 days. Relative risks and 95% CIs.

Supportive analyses

Patients with less than 4 days hospital stay and day cases

We examined the effect of achieving 90% VTE risk assessment on primary and VTE related deaths within 90 days of discharge in patients with hospital length of stay of less than 4 days and in day cases. There were 13 571 420 admissions with less than 4 days stay excluding day cases. In this cohort, there were 874 VTE related deaths, and 512 primary VTE deaths. There were 9 534 178 day cases with 393 VTE related deaths and 192 primary VTE deaths.

Achieving the VTE risk assessment target was significantly associated with a reduction in death within 90 days of discharge both for primary VTE deaths (RR 0.61; 95% CI 0.48 to 0.79; p=0.0002) and for VTE related deaths (RR 0.74; 95% CI 0.61 to 0.90; p=0.003) in patients with less than 4 days hospital stay (figure 3). There was no evidence of an effect of achieving the VTE assessment target on deaths within 90 days among day cases however (figure 4).

Figure 3

Effect of achieving venous thromboembolism (VTE) risk assessment quality standard on mortality outcomes within 90 days of discharge in admissions <4 days. Relative risks and 95% CIs.

Figure 4

Effect of achieving venous thromboembolism (VTE) risk assessment quality standard on mortality outcomes within 90 days of discharge in day cases. Relative risks and 95% CIs.

Effect of implementing VTE risk assessment policy on surgical and non-surgical admissions

We examined the effect of implementing the VTE risk assessment policy on patients by whether surgical procedures were undertaken (surgical group) or not (non-surgical group) during the index admission. We analysed data on patients with a hospital stay of more than 3 days, and those less than 4 days (excluding day cases) (see table 1). Numerically, VTE events in the surgical group were lower in comparison with the non-surgical group. We also analysed the data for day cases shown in figure 4 separately for the surgical and non-surgical groups and found no evidence of an effect in either (data not shown).

Table 1

Effect of achieving venous thromboembolism (VTE) risk assessment quality target on patients by whether they were coded for a surgical room procedure or not during the index admission, examining those patients admitted for more than 3 days, and those admitted for less than 4 days (excluding day cases)

Non-surgical group

For 2 590 547 non-surgical admissions with more than 3 days hospital stay, implementing the VTE risk assessment policy did not influence VTE related deaths within 90 days of discharge. There were 1135 such events and the CIs on the estimates were reasonably narrow. Primary VTE deaths within 90 days of discharge and VTE related inhospital deaths were all associated with around 10% reduction in risk, and the reduction in VTE related inhospital deaths was modestly statistically significant.

Among 10 719 502 non-surgical admissions with less than 4 days hospital stay (excluding day cases), we saw strong and convincing reductions in deaths within 90 days of discharge for both primary VTE and VTE related deaths.

Surgical group

In 1 550 794 admissions coded for a surgical room procedure with greater than 3 days hospital stay, we found no evidence of a convincing effect of implementing the VTE risk assessment policy on inhospital VTE mortalities (primary or related), but primary VTE deaths within 90 days of discharge were significantly reduced in this group. The risk of VTE related death within 90 days of discharge was reduced by 18%, but was not statistically significant although the number of contributing events was modest.

In 2 851 838 surgical admissions less than 4 days (excluding day cases), the number of deaths for all analyses was modest leading to quite wide CIs. All the RR values were less than one.

Examining the proportion of patients risk assessed

In examining the proportion of risk assessments performed in each hospital trust by month rather than by the ≥90% target, all analysis provided qualitatively similar results to those seen in figure 2. For example, the total effect on primary VTE death in the principle analysis provided an estimate RR 0.88 (95% CI 0.79 to 0.98; p=0.02).


In 2010, the Department of Health in England introduced a quality incentive for NHS hospital trusts to screen at least 90% of admitted patients for the risk of developing VTE. We found that the achievement of this quality standard was associated with a significant overall reduction in mortality due to VTE (inhospital and within 90 days from discharge). This finding was detected in patients with hospital stay greater than 3 days, whom we judged most likely to be at risk of developing VTE and most likely to receive thromboprophylaxis, and for admissions with hospital stay less than 4 days. We did not detect any effect on day case VTE mortality. Numerically, VTE events were more common in patients not undergoing a surgical room procedure during their index admission, although there are considerably more of these admissions and the overall risk is similar.

A strength of our analyses is that we accounted efficiently for time effects using random effects radial smoothers. We also included trusts as random intercept terms. This is important as trusts were not the same in patient characteristics (including eye hospitals and tertiary specialist centres for other conditions along with district general hospitals), which was highlighted by the fact that nine hospital organisations never achieved the quality standard for VTE risk screening during the study period, and nine trusts achieved the standard for the entire period.

One potential bias is that a reduction in deaths in those who have survived to day 4 of an admission from VTE requires them to have survived for the first 3 days, and early deaths could be a form of competing risks, that is, an increase in early deaths (before 4 days) could give the impression of a decrease in later deaths (from day 4). We assessed this by examining VTE inhospital mortality (including all deaths which occurred in hospital) for subjects with admissions less than 4 days. These analyses showed a non-significant reduction in all VTE deaths (RR 0.95; 95% CI 0.84 to 1.08; p=0.46) and in deaths with VTE in the primary position on the death certificate (RR 0.89; 95% CI 0.75 to 1.07; p=0.21), thus providing no evidence of competing risks. A further potential limitation is the accuracy of coding which is controversial.10 This is more likely to be an issue with HES admission coding rather than death certification, which although flawed,11 represents a more concrete outcome determined by a clinician involved in patient care or else a coroner's postmortem determining the cause of death. Our methodology was designed to identify hospital associated VTE mortality occurring during an admission after more than 3 days with exclusion of patients where VTE was the primary reason for admission. As the effectiveness of this method relies on the quality of coding in hospitals across the country (which cannot be individually tested in our study), an unknown number of community acquired events with delayed death could have been assigned as hospital associated. There has been no step change in the hospital management of community acquired VTE over the study period and so this should not impact on the interpretation of our results. Other important considerations are that a VTE death within 90 days of discharge may not be directly attributable to the hospital admission itself but related to patient comorbidities and many events occur despite using thromboprophylaxis according to local protocols.12 Therefore, events which are truly preventable by VTE risk assessment and appropriate thromboprophylaxis are an unknown proportion of this cohort.

In our analysis plan we defined the achievement of the 90% VTE screening assessment, which helps avoid a financial penalty for the hospital organisation, as the main explanatory variable, as this was the standard identified by the programme. However, if instead we took the actual quality score by month as the explanatory variable in supportive analyses, we found a qualitatively similar pattern of results. Because we do not know which individual patients were risk-assessed and which were not in each hospital organisation, we cannot (without making considerable additional assumptions) estimate directly the effect on absolute VTE risk of conducting a risk-assessment on an individual patient or number needed to treat (NNT) to save a life.

Our data do not allow an indepth analysis of the mechanisms underlying the reduction in mortality. Making clinicians aware of patient VTE risk during hospital admission has been shown to reduce VTE events.13 ,14 It is possible that introduction of the CQUIN target is associated with increasing use of pharmacological thromboprophylaxis and with increasing staff and patient awareness of the symptoms and signs of VTE and the adoption of simple non-pharmacological strategies to reduce the risk. This may explain the reduced mortality in the patients admitted for less than 4 days as it is likely that most of these patients receive little in the way of pharmacological prophylaxis. Increased awareness of VTE symptoms might also explain the apparent reduction in VTE mortality without an observed reduction in non-fatal VTE readmissions (which may be paradoxically increased). It has been estimated that about 60% of patients with fatal VTE have prodromal symptoms which are often misinterpreted, representing a missed opportunity to prevent a fatal outcome.2 In this study, the reduction of primary VTE deaths associated with ≥90% risk assessment in patients admitted for more than 3 days not having a surgical procedure seems to occur during admission but not clearly after discharge. Postdischarge pharmacological thromboprophylaxis is rarely given to this group of patients (unlike high risk surgical and obstetric patients) and transition to a reduced VTE risk may not be quite so apparent as with surgical patients after discharge. In contrast, it is postdischarge primary VTE deaths which appear to have been prevented in those having surgical procedures requiring admission for more than 3 days. Pharmacological thromboprophylaxis gives a greater degree of VTE risk reduction in surgical patients than in medical patients (70% vs 50%)15 ,16 and these patient groups differ in terms of comorbidities, VTE risk factors and response to treatment. In trials of pharmacological prophylaxis in medical patients, no reduction of overall mortality has been detected.17 In our analysis of large numbers of ‘real world’ patients, a reduction in primary VTE mortality was detected. However, our study does not address the harms of any increase in pharmacological prophylaxis as a result of increased VTE risk assessment. Bleeding complications with pharmacological thromboprophylaxis may offset the benefits, particularly in medical patients.18

The aim of the VTE CQUIN in England was to reduce avoidable death, disability and chronic ill health from VTE.4 Achieving the target of 90% or more patients’ risk assessment avoided a financial penalty of approximately £0.5 million a year for many acute hospital trusts. The CQUIN uses the risk of withholding money already allocated to a hospital baseline budget to drive specific quality targets. It is therefore a financially attractive method for commissioners of healthcare to achieve desired targets without financial investment, albeit at the risk of diverting attention away from healthcare outcomes not subject to such penalties. Our analyses provide convincing evidence of the effectiveness of the VTE risk screening programme in the English NHS. Taking the year 2011 as the basis for this estimation, if all trusts achieved the quality standard, we could expect as a result that 280 (95% CI 25 to 532) deaths from VTE (anywhere in the first three positions on the death certificate) would have been avoided among patients with admissions greater than 3 days. In addition, we could expect that 150 deaths (95% CI 58 to 225) within 90 days of discharge would have been prevented among subjects with admissions less than 4 days. It is likely that this is an underestimate of the true number of VTE fatalities19 and the low rate of postmortems preformed in England has been identified as contributing to this under-recognition.20

In summary, this study demonstrates that a national quality initiative to increase the number of patients screened for VTE risk to at least 90%, linked to a financial penalty, has resulted in improvements in the outcome of death from VTE up to 90 days after hospital admission. Ideally, future similar initiatives should be delivered in conjunction with predefined methodology to assess their efficacy and impact. In terms of implications for clinical practice, this study reinforces the value of implementing strategies to increase the number of patients risk assessed for VTE on admission to hospital. Ideally, future research should attempt to assess the impact of increasing VTE risk assessment on patient and staff awareness and on the use of thromboprophylaxis and whether there are any measurable harms resulting from this.


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  • Contributors WL: Conception, design, interpretation of data and drafting the manuscript. NF and JW: Conception, design, statistical analysis, interpretation of data and revision of content. IB: Conception, design, data extraction and revision of content. DR: Conception, data extraction and revision of content. DP: Conception, design and interpretation of data, revision of content, and final approval.

  • Funding QUORU is funded solely by University Hospital Birmingham NHS Foundation Trust.

  • Competing interests WL reports serving on advisory boards for Bayer and Boehringer Ingelheim and has received lecture fees from Bayer, Boehringer Ingelheim and Sanofi Aventis and received financial support for attendance of an educational meeting from Boehringer Ingelheim. NF has received funding for consulting, research and travel from Sanofi Aventis.

  • Ethics approval Institutional Study Registration was obtained by UHB-QE (CAB-04920-12).

  • Provenance and peer review Not commissioned; externally peer reviewed.

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