Footnotes

• Contributors RW and KG drafted the manuscript. All authors critically revised the manuscript and approved the final version. RW is the guarantor.

• Competing interests RW reports being the local principal investigator of a clinical study sponsored by Medtronic (Cryptogenic Stroke and Underlying Atrial Fibrillation; NCT00924638) and receiving speaking fees from Medtronic. No other potential conflict of interest to relevant to this article was reported.

• Provenance and peer review Commissioned; internally peer reviewed.