Objective To investigate the gender difference of bleeding in acute myocardial infarction patients aged 80 and over.

Methods Life-threatening bleeding and major or minor bleeding is defined according to TIMI criteria. In a cohort of AMI patients aged ≥ 80 years from 2003 to 2012 at CCU department in fuxing hospital, the bleeding condition and the gender difference of bleeding was evaluated.

Results 386 patients presenting with ST segment elevation AMI (STEMI) and non-STEMI were enrolled, which included 189 male and 197 female. Bleeding was observed in 37.6% of male and in 43.1% of female, Pearson chi-square showed that there was no gender difference in bleeding during hospitalisation, X² = 1.248, P = 0.264.

In the male patients, 2.8% of TIMI life-threatening bleeding, 19.7% of major and 77.5% of minor bleeding were discovered. 4.7% of TIMI life-threatening bleeding, 7.1% of major bleeding and 88.2% of minor bleeding were observed in the female patients. There was no significant gender difference in TIMI bleeding, X² = 5.802, P = 0.057.

Conclusions Our study demonstrates that no significant gender difference in TIMI bleeding in oldest-old patients with AMI is discovered.