Objective Acute coronary syndrome (ACS) remains an important cause of mortality and morbidity. Identification of circulating biomarkers to evaluate cardiovascular event risk and pathology prognosis is of particular importance. Microparticles (MP) is cell-derived fragments known to be increased in the blood of patients with acute coronary syndromes. But the cellular origin of circulated microparticles in ACS patients still unknown. We investigated whether red blood cell derived microparticles (RMPs) can contribute to Xinjiang Uiygur patients suffered from Acute coronary syndrome.
Methods fourty-nine acute coronary syndrome patients for Uiygur population underwent successful primary percutaneous coronary intervention (PCI) were enrolled and were compared with age-matched 40 cases healthy control. The blood samples were sequentially drawn from veinous before operation. Red blood cell derived microparticles (RMPs, Glycophorine A+) were determined by flow cytometry.
Results Red blood cell derived microparticles (RMPs) were elevated in ACS compared with control, P < 0.001.
Conclusions Acute coronary syndrome patients for Uiygur population, the level of circulated Red blood cell derived microparticles (RMPs, Glycophorine A+) were significantly higher than control. The association between large RMPs and ACS support the hypothesis that bleeding after plaque rupture may contribute to atherosclerosis development. RMPs might be a diagnostic marker related to ongoing thrombosis in ACS from Xinjiang Uiygur population. A large prospective study is needed to establish the role of RMPs as an independent risk factor for ACS.