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ASSA13-02-24 Trans-Brachial Approach with a Standard Electrophysiology Catheter is Also Feasible For Renal Sympathetic Denervation: A Chinese Experience
  1. Lu Chengzhi,
  2. Xu Jianqiang,
  3. Zhao Xiangdong,
  4. Xia Dasheng,
  5. Chen Xin,
  6. Yu Xiang
  1. Tianjin First Central Hospital


Objective Renal denervation by radiofrenquency (RF) catheter could result in a significant lowering of blood pressure (BP). This study aims to examine the feasibility and safety of renal denvervation by a standard electrophysiology (EP) catheter and trans-brachial approach for Chinese patients suffered from resistant hypertension.

Methods From August 2011 to December 2011, a total of 17 resistant hypertension patients received percutaneous renal artery ablation by a standard RF catheter (Celsius®, Innercool Therapies, Inc, Johnson&Johnson, USA). Patients were divided into trans-brachial group or trans-femoral group by the operator’s desire and followed up for 3 month after the index procedure. Blood samples were taken to evaluate the effects on renal function.

Results There is no difference of BP decrease (systolic BP: 41.8 ± 37.0 mmHg in trans-brachial group vs. 21.4 ± 16.6 mmHg in trans-brachial artery group, p = 0.172; diastolic BP: 23.1 ± 24.4 mmHg vs. 14.9 ± 13.2 mmHg, p = 0.396) between the 2 groups. The trans-brachial group has a tendency of longer procedure time (117.2 ± 36.0 min vs. 89.4 ± 16.4 min, p = 0.063) and fluoroscopy time (26.8 ± 7.9 min vs. 20.1 ± 4.8 min, p = 0.057) comparing with trans-femoral group. The renal function presented by eGFR didn’t change (118.8 ± 101.0 ml/min/1.73m2 vs. 85.4 ± 48.4 ml/min/1.73m2, p = 0.29).

Conclusions Catheter-based renal denervation by a standard EP catheter seems an attractive novel minimally invasive treatment option in patients with resistant hypertension, and trans-brachial approach is also feasible for this new promising therapy.

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