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ASSA13-03-5 Effects of Pioglitazone on Atrial Ionic Channel Remodelling in Diabetic Rabbits Hearts
  1. Liu Changle,
  2. Li Guangping,
  3. Fu Huaying,
  4. Li Jian,
  5. Cheng Lijun,
  6. Yang Wansong,
  7. Liu Tong
  1. Department of Cardiology, 2nd Hospital of Tianjin Medical University, Tianjin, China 2nd Hospital of Tianjin Medical University, Tianjin, China

Abstract

Objective We investigated the effects of pioglitazone on atrial ionic channel remodelling in alloxan-induced diabetic rabbits, and electrophysiological mechanisn of pioglitazone on atrial fibrillation.

Methods 32 rabbits were divided into CN group, DM group, DPG group and DPI group. Langendorff-perfused rabbit hearts were used to isolate single atrial myotcyte, and whole-cell patch-clamp technique was used to record action potential duration (AP) and atrial ionic channel currents (ICa, L and INa).

Results Compared with controls, APD90 and APD50 of left atrial myocytes were significantly prolonged in DM group (P < 0.05 vs. CN), and APD90 rate adaptation was no significant differences (P > 0.05 vs. CN). The densities of INa were reduced and the densities of ICa, L were increased in DM group (P < 0.01 vs. CN). The above were markly attenuated in DPG and DPI group.

Conclusions Pioglitazone may prevent atrial ionic channel remodelling in diabetic rabbits, even play an important prevention to DM-related AF.

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