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ASSA13-03-6 Effects of Renal Sympathetic Denervation on the Development of Atrial Fibrillation Substrates in Dogs with Pacing-Induced Heart Failure
  1. Qingyan Zhao,
  2. Shengbo Yu,
  3. Jinping Xiao,
  4. Zixuan Dai,
  5. Xule Wang,
  6. Congxin Huang
  1. Cardiovascular Research Institute of Wuhan University, Renmin Hospital of Wuhan

Abstract

Objective We examined the role of renal denervation on the inducibility of AF in dogs with pacing-induced HF.

Background Atrial fibrillation (AF) and heart failure (HF) are common interrelated conditions that are associated with renin-angiotensin-aldosterone system activity.

Methods and Results Nineteen dogs were randomised into sham-operated (7 dogs), HF (6 dogs) and HF+renal artery ablation (RAA, 6 dogs) groups. Sham-operated dogs were implanted with transvenous cardiac pacemakers without pacing. Dogs in the HF group were implanted with pacemakers and underwent right ventricular pacing for 3 weeks at 240 bpm to induce HF. The dogs in the HF+RAA group received double renal artery ablation. The dogs recovered for 8 weeks and underwent the same HF-inducing procedure. Compared to the baseline, the atrial dimensions increased and the right atrial ERP (131 ± 14 ms to 112 ± 12 ms, p = 0.02) decreased significantly after 3 weeks in the HF dogs but not the HF+RAA dogs. A greater number of AFs were induced in the HF dogs than the HF+RAA dogs (2.2 ± 0.6 vs. 0.3 ± 0.3, p = 0.03). The atrium from HF hearts revealed a large amount of fibrosis, whereas control and HF+RAA dogs showed minimal fibrous tissue. The levels of BNP, Ang II, TNF-α and expression of TGF-β and Cx43 in atrial tissue were increased in the HF dogs compared to the sham-operated and HF+RAA dogs.

Conclusion RAA suppressed the atrial substrate remodelling and the AF vulnerability that was induced by long-term rapid ventricular pacing.

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