Objective To explore the association of C-reactive protein (CRP) gene C+1444T polymorphism with acute myocardial infarction (AMI).
Methods 289 patients with AMI (AMI group) and 285 subjects (control group), who were free of coronary artery disease by coronary angiography, were recruited in inpatients between November 2003 and May 2008 from Affiliated Wujin Hospital of Jiangsu University and First Affiliated Hospital of NanJing Medical University. The CRP gene C+1444T polymorphism was determined by polymerase chain reaction and restriction fragment length polymorphism analysis.
Results There was no statistical differences of the frequencies of CC, CT and TT genotype between AMI group and control group (83.39% vs 86.70%, 14.53% vs 12.30% and 2.08% vs 1.10%, respectively; P value was 0.754, 0.489 and 0.331, respectively). The prevalence of C allele was 90.66% and 92.80% for AMI group and control group, respectively (P = 0.784). Furthermore, after adjustment for multivariate such as age, gender, smoking, systolic pressure, diastolic pressure, blood glucose, blood-lipoids by multivariate logistic regression analysis indicated that there was no significant correlation between the CRP gene C+1444T polymorphism and attack of AMI (P > 0.05).
Conclusions The present findings suggest that the CRP gene C+1444T polymorphism has no relation to the likelihood of AMI in the Chinese Han population of Suwan region.