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ASSA13-03-25 Plasma and Urine Tranexamic Acid Concentrations of Tranexamic Acid During Cardiopulmonary Bypass in Infants with Tetralogy of Fallot
  1. Sun Guolin,
  2. Wen Renguo,
  3. Ma Ruiyan,
  4. Chen Jinjin,
  5. Xiao Yingbin
  1. Department of Cardiovascular Surgery, Xinqiao Hospital, Third Military Medical University

Abstract

Objective To study the plasma and urine concentration of tranexamic acid (TA) during cardiopulmonary bypass in infants with Tetralogy of Fallot.

Methods 5 patients with Tetralogy of Fallot received an initial dose 100 mg/kg of TA given over 10 min followed by an infusion of 100 mg/kg before the initiation of cardiopulmonary bypass (CPB). TA was measured in urine using with 1H NMR S.

Results Plasma TA concentrations (ug/mL; Mean ± SD) were 224.61 ± 195.28 at 20 min after bolus, 509.58 ± 181.571 after 60 min on CPB, 243.95 ± 32.30 at the end of operation. Urine TA concentrations (mg/mL; M ± SD) before CPB, during CPB, thoracic closing and 4 hours after operation, 4.28 ± 1.12, 3.7 ± 2.86mg/ml, 4.45 ± 2.65mg/ml, 1.20 ± 0.61mg/ml respectively. Total urine TA dose (mg; M ± SD) before CPB, during CPB, and thoracic closing, 157.5 ± 24.8, 207.20 ± 116.20mg, 485.40 ± 326.52mg respectively. The TA excrete (M ± SD) is 56.218 ± 27.61% until operation finished about 3 hours.

Conclusions A 100mg/kg initial dose of TA followed by an infusion of 100mg/kg before the initiation of CPB is sufficient enough to provide an effective plasma concentration125ug/ml for the bleeding patients with high risk. The dose of TA could be decreased.

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