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ASSA13-01-11 The Correlation of the Serum C-Reactive Protein Leve with Its Gene T-757C Polymorphism in Patients with Acute Myocardial Infarction
  1. Guoping He,
  2. Haitao Yang
  1. Affiliated Wujin Hospital of Jiangsu University, Changzhou, China

Abstract

Objective To explore the association of the serum C-reactive protein (CRP) level with the CRP gene T-757C polymorphism and risk of acute myocardial infarction (AMI) in Chinese Han population of Sunan region.

Methods The CRP gene T-757C polymorphism was genotyped by polymerase reaction restriction-fragment length polymorphism analysis, and the serum CRP level was measured by enzyme-linked immune sorbent assay in 213 AMI patients (AMI group) and 173 subjects without coronary heart disease (CHD) (control group).

Results ➀In Chinese Han population of Sunan region, there were CRP gene T-757C polymorphisms in patients with AMI and in subjects without CHD; ➁The serum CRP level in AMI patients (5.985/6.527μg/ml) was significantly higher than those in non CHD subjects (3.262/1.356μg/ml) (P < 0.01) and there were still significant differences after adjustment for gender, age, smoking, hypertension, diabetes and dyslipidemia (P < 0.01); ➂In AMI patients, no significant differences were found in the serum CRP level among any genotype (CC, TC or TT) of the CRP gene T-757C (4.069/2.493 pg/ml vs 5.745/6.321 pg/ml vs 6.127/6.629 pg/ml), and there also were no significant differences in the serum CRP level among any genotypes in this locus within the same gender and age (P > 0.05).

Conclusions The serum CRP level in AMI patients is significantly higher than those in non CHD subjects but not influenced by CRP gene T-757C polymorphism in Chinese Han population of Sunan region.

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