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ASSA13-01-12 The Effects of Monocyte Chemoattractant Protein-1 Gene A-2518G Polymorphism, Its Serum Levels on AMI in Chinese Han Population of Sunan Region
  1. Guoping He,
  2. Jiu Jiang
  1. Affiliated Wujin Hospital of Jiangsu University, Changzhou, China

Abstract

Objective To investigate the effects of monocyte chemoattractant protein-1 (MCP-1) A-2518G genetic polymorphism and its serum levels on acute myocardial infarction (AMI) in Chinese Han population of Sunan region.

Methods The A-2518G polymorphism of MCP-1 gene was genotyped in 338 patients with AMI and 192 control subjects by polymerase chain reaction and restriction fragment length polymorphism analysis and DNA sequencing; Serum concentration of MCP-1 was randomly measured in 94 patients with AMI and 73 control subjects by enzyme-linked immune sorbent assay.

Results Significant difference was found neither in genotype distribution nor in allele frequencies of MCP-1 gene A-2518G between AMI and controls (GG:31.36%, AG:52.66%, AA:15.98% in AMI; GG:34.37%, AG:53.65%, AA:11.98% in controls (P = 0.428), the G allele prevalence was 0.5769 in AMI group and 0.6120 in control subjects (P = 0.270). Multivariate logistic regression analysis revealed that MCP-1 gene –2518G allele was not associated with increased risk of AMI [χ2 = 0.408; P = 0.523; OR: 0.800 (0.404–1.585) ]. The serum level (M/IQR) of MCP-1 was significantly higher in AMI group (186.24/285.15) pg/ml than that in controls (100.71/134.02) pg/ml (P = 0.001). Multiple linear regression analysis further revealed that the serum levels of MCP-1 was associated with hypertension, diabetes mellitus, smoking and male, but not with MCP-1 gene –2518G allele in AMI group. Multivariate logistic regression analysis revealed an elevated serum level of MCP-1 was not associated with increased risk of AMI [χ2 = 2.665; P = 0.103; OR:2.782 (0.814–9.505) ].

Conclusions Neither the MCP-1 gene A-2518G polymorphism nor its serum levels was associated with increased risk of AMI, and the MCP-1 gene A-2518G polymorphism does not yet effect its serum levels in Chinese Han population of Sunan region.

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