Objective To approach Effect of benazepril on left ventricular hypertrophy and left ventricular function (LVF) of primary hypertension.
Methods 78 patients of primary hypertension were randomly divided into 2 groups. Benazepril was prescribed to 39 patients as test group with a dosage of 10mg/day, while 39 patients as test group take nifedipine controlled release pellets 10mg ∼ 20mg/d. The total course of treatment was 6 months. All patients were examined by colour Doppler pre and post-therapy for data about the heart, such as left ventricular mass index] (LVMI), left ventricular end-diastolic dimension (LVEDD) and left ventricular ejection fraction (LVEF).
Results Blood pressure significantly decreased in both 2 groups (P < 0.01), and the decrease was nonsignificant between 2 groups. LVMI significantly decreased post-treatment in test group (P < 0.05), while in control group the difference between pre and post-treatment was nonsignificant (P > 0.05). LVEDD and LVEF both significantly improved post-treatment in test group (P < 0.05). In control group the improvement was nonsignificant (P > 0.05).
Conclusions Benazepril has reverse effect on heart reconstitution and left ventricular function in addition to its effect on hypertension.