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ASSA13-10-18 Effect of Benazepril on Left Ventricular Hypertrophy and Left Ventricular Function (LVF) Of Primary Hypertension
  1. Yao Gongyuan1,
  2. Li Hexun1,
  3. Li Shuangfei1,
  4. Ma Xinhua2,
  5. He Zhiming2
  1. 1ShenZhen FuTian No.2 People’ Hospital (ShenZhen, CN)
  2. 2Hospital Affiliated to Shaoyang Medical College (Shaoyang, CN)

Abstract

Objective To approach Effect of benazepril on left ventricular hypertrophy and left ventricular function (LVF) of primary hypertension.

Methods 78 patients of primary hypertension were randomly divided into 2 groups. Benazepril was prescribed to 39 patients as test group with a dosage of 10mg/day, while 39 patients as test group take nifedipine controlled release pellets 10mg ∼ 20mg/d. The total course of treatment was 6 months. All patients were examined by colour Doppler pre and post-therapy for data about the heart, such as left ventricular mass index] (LVMI), left ventricular end-diastolic dimension (LVEDD) and left ventricular ejection fraction (LVEF).

Results Blood pressure significantly decreased in both 2 groups (P < 0.01), and the decrease was nonsignificant between 2 groups. LVMI significantly decreased post-treatment in test group (P < 0.05), while in control group the difference between pre and post-treatment was nonsignificant (P > 0.05). LVEDD and LVEF both significantly improved post-treatment in test group (P < 0.05). In control group the improvement was nonsignificant (P > 0.05).

Conclusions Benazepril has reverse effect on heart reconstitution and left ventricular function in addition to its effect on hypertension.

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