Objective To investigate the characteristics and related risk factors of arterial elasticity in persons with prehypertension, high-normal blood lipid and/or impaired glucose regulation (impaired fasting glucose and/or impaired glucose tolerance).
Methods After receiving physical and biochemical examinations, a totol of 1238 persons were enrolled in this study. Among these enrolled persons, 65 persons were with prehypertension, 156 persons with high-normal blood lipid, 159 persons with impaired glucose regulation, 85 persons with prehypertension and high-normal blood lipid, 77 persons with prehypertension and impaired glucose regulation, 55 persons with high-normal blood lipid and impaired glucose regulation, 9 persons with prehypertension, high-normal blood lipid and impaired glucose regulation. 332 healthy persons, 113 hypertensive patients, 150 hyperlipidemic patients and 37 diabetic patients were enrolled as controls. Systemic vascular compliance (SVC), systemic vascular resistance (SVR), brachial artery distensibility (BAD) of all persons were measured with Dynapulse 200 M (Pulse Metric, Inc., USA).
Results In persons with prehypertension, SVC was lower than healty group (P < 0.0001) and higher than hypertensive group (P = 0.0109), SVR was higher than healty group (P = 0.0123) and lower than hypertensive group (P < 0.0001), BAD was lower than healty group (P < 0.0001). Among different groups with prehypertension, high-normal blood lipid and/or impaired glucose regulation, SVC, SVR and BAD were all with significant differences. Multiple linear regression analysis indicated, blood pressure was the independent risk factor of arterial elasticity.
Conclusions Vascular function had been damaged in prehypertensive stage. Blood pressure was the independent risk factor, which had more strong effect than lipid and blood glucose. More cardiovascular risk factors with high-normal value will affect vascular function more strongly.