Objective D-dimer is a primary degradation product of thrombus. Whether it will be increased in myocardial infarction is still controversial. To study the change of D-dimer in coronary artery disease, this study investigated the level of plasma D-dimer in different type AMI patients at different stage.

Methods The study group consisted of 200 patients suffered with acute coronary syndrome (ACS) from Jan 2011 to Jun 2012. 100 of the patients were diagnosed as STEMI; the rest was NSTEMI. And 100 patients excluded organic disease were enrolled as the contrast group. Blood was drawn at the time of admission, 12h and 24 hours after that. The samples were measured for cTnI, BNP, hs-CRP and fibrin D-dimer. All ACS patients were underwent active PCI strategy.

Results Mean age of these patients was 65.6 years. Female is about 41.2% and male about 58.8%. In patients with STEMI, the level of cTnI, BNP and hs-CRP was significantly higher than that in patients without organic disease at the time of admission, 12h and 24h after that. While the level of D-dimer was not significantly different among the three groups at any time. The data is 103.4 ± 13.3ug/l, 108.2 ± 9.4ug/l and 98.5 ± 12.6ug/l in STEMI patients at the time of admission, 12h and 24h after that, respectively. The level of D-dimer is 103.1 ± 11.3ug/l, 97.8 ± 8.6ug/l and 98.6 ± 11.6ug/l in NSTEMI patients at the time of admission, 12h and 24h after hat, respectively. The contrast patients data is 96.4 ± 9.3ug/l, 98.3 ± 8.6ug/l and 95.5 ± 10.2ug/l at the time of admission, 12h and 24h after that, respectively.

Conclusions Early level of circulating cTnI, BNP and hs-CRP was significantly higher in ACS, while there was no dynamic change of D-dimer level in patients with ACS, whatever STEMI or NSTEMI.