Objective To investigate the effect of different body mass index (BMI) and waist circumference on arterial elasticity in essential hypertension.
Methods The basic information was collected in a total of 776 essential hypertensive patients. According to BMI and waist circumference level, all patients were divided into four groups, namely, normal BMI and normal waist circumference group (Igroup, n = 194 cases), normal BMI and elevated waist circumference group (IIgroup, n = 195 cases), excessive BMI and normal waist circumference group (III group, n = 196 cases), excessive BMI and elevated waist circumference group (IVgroup, n = 191 cases). Brachial ankle pulse wave velocity (baPWV) and ankle-brachial blood pressure index (ABI) were observed in all patients. Arterial stiffness index (AI) was calculated using the blood lipid of all hypertension patients.
Results baPWV (2120 ± 263) and AI (3.35 ± 0.87) in IV group were significantly higher than Igroup (P < 0.01), IIgroup and III group (P < 0.05). ABI (0.72 ± 0.15) in IV group were significantly lower than Igroup (P < 0.01), IIgroup and III group (P < 0.05). There were no statistical differences between IIgroup and III group in ABI and AI (P > 0.05). Results of 2 × 2 factorial analysis showed that there was a distinctive and synergistic effect between excessive BMI and elevated waist circumference on arterial stiffness.
Conclusions Arterial elasticity function was aggravated damaged in essential hypertension in patients with abdominal obesity. Excessive BMI and elevated waist circumference had interaction and synergistic effect on the damage of arterial elasticity function.