Objective To investigate the clinical characteristics of the kidney post-transplantation, including the incidence of the post-transplant hypertension, the buck compliance rate of the patients with hypertension and the difference study over the renal transplant patients.
Methods (1) We present the retrospective analysis and the followed up study over the 406 clinical cases of the patients who were taken the kidney transplantation at the kidney disease centre, in the Third Xiangya Hospital Central South University, from January 2007 to December 2011. The study population was divided into two groups accordingly: non post-transplant hypertension was crowded as the groupI, and the post-transplant hypertension was crowded as the group II, and to analyse related clinical features of post-transplant hypertension (2) Grouping the post transplantation hypertension patients with the combination treatment programme into CsA and FK506 two group respectively, we compared the occurrence time and the blood pressure of the post transplantation hypertension (PTH) over the post operation patients, and analysed of the differences between the combination therapy of renal transplant patients with deducting blood and personal affects.
Results (1) The incidence of post-transplantation hypertension (PTH) was 64%. (2) There were no Differences between Two treatment Protocols of anti-hypertension. After 12-weeks treatment, the reduction in systolic blood Pressures (group CsA: 28.0 ± 11.2 mmHg vs. group FK506 24.5 ± 10.8 mmHg) (P < 0.05) and in diastolic blood Pressures (13.2 ± 10.5mmHg vs. 13.7 ± 7.8 mmHg) was Similar in two groups. The efficacy of deduction of blood Pressure was 83.2%in group CsA and 81.9% in group FK506 (P > 0.05), and the Percentage of Blood control were 76.5% (P > 0.05) vs. 77.8% (P > 0.05).
Conclusions (1) According to our statistic, the incidence of post-transplantation hypertension (PTH) is very high, so we should take some measures to intervene in relevant risk factors of PTH. (2) Group CsA of subject’s systolic blood pressure decreased more significantly, with group FK506 is significant, diastolic blood pressure shows no significant difference. After combination therapy for a period of time, two sets of blood pressure decline were stable, no statistically significant differences between groups.