Article Text

PDF
ASSA13-14-23 Relationship of Renal Function and Left Ventricular Hypertrophy in Refractor Hypertension
  1. Kuang Ze-min1,2,
  2. Yuan Hong1,2,
  3. Kong Yu3,
  4. Huang Su-lan3,
  5. Yu Zhen-qiu3
  1. 1Department of Cardiovascular, The Third Xiangya Hospital of Central South University
  2. 2Clinical Pharmacology Center, The Third Xiangya Hospital of Central South University
  3. 3Department of Hypertension, Beijing Anzhen Hospital of Capital Medical University

Abstract

Objective To study the relationship between renal function and left ventricular hypertrophy (LVH) in patients with refractory hypertension (RH), and to investigate the relative risk factors of LVH in RH patients.

Methods 215 (120 cases of RH and 95 cases of none RH) hospitalised patients were retrospectively analysed. The renal function was evaluated by modification of diet in renal disease (MDRD) formula, and 24h ambulatory blood pressure was monitored. Echocardiography measurement was performed, and left ventricular mass index (LVMI) were calculatled. LVH were definited when LVMI > 125g/m2 in male or LVMI > 110g/m2 in female.

Results Compared with that in none RH group, estimated glomerular filtration rate (eGFR) in RH group was lower[(72.3 ± 22.1) vs (83.1 ± 19.5)ml/(min.1.73m2), P < 0.01], while the detectable rates of eGFR < 60 ml/(min.1.73m2), LVH, secondary hypertension, and LVMI in RH group were higher[29.2%vs10.5%, 32.5%vs 16.8%, 31.7%vs5.3%,(108.0 ± 27.1)vs (95.3 ± 22.9) g/m2, respectively]. These differences had statistic significance (all P < 0.05). The logistic regression analysis showed that OR value of eGFR < 60ml/(min.1.73m2) and concomitant hypercholesteremia were 4.5(95%CI 1.82–1.07, P = 0.001) and 3.6(95%CI 1.36–9.58, P = 0.010), respectively.

Conclusions Renal function and LVH are evident in RH patients. Different levels of renal function had different impacts on LVH. eGFR < 60ml/(min.1.73m2) is a relative risk factors of LVH.

Statistics from Altmetric.com

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.