Objective To investigate the relationship between variability of self-measured blood pressure at home (HBPV) and carotid artery atherosclerosis and endothelial function in normotensive and mild-moderate hypertensive individuals.
Methods Seven consecutive days HBP monitoring, carotid artery ultrasound, brachial artery flow-mediated dilation (FMD) were performed in 314 volunteers. HBPV was assessed by the standard deviations of the daily BP average of the last 6 consecutive days. Plasma endothelin-1 level was tested using ELISA.
Results The tendency of systolic HBPV significantly increased from normotension to moderate hypertension group. Systolic HBPV was closely correlated with carotid intima-media thickness (IMT) (r = 0.569, p < 0.001), stiffness parameter β (r = 0.447, p < 0.001), FMD (r = –0.636, p < 0.001), and endothelin-1 (r = 0.649, p < 0.001). Diastolic HBPV was correlated with carotid IMT, stiffness parameter β, FMD, and endothelin-1, but the strength of the correlation was weaker than systolic HBPV (All p < 0.001). After adjusted all covariants, only systolic HBPV was always significantly associated with carotid IMT, stiffness parameter β, FMD, and endothelin-1.
Conclusions HBPV was increasing with BP level elevated. It significantly associated with carotid artery atherosclerosis and endothelial function in normotensive and mild-moderate hypertensive subjects.