Objective To investigate lipid levels in Chinese elderly patients with acute myocardial infarction (AMI), subsequently to grasp the characteristics of dyslipidemia and improve lipid control.
Methods A retrospective analysis of 1213 patients hospitalised with AMI in our hospital from May 2007 to July 2011. Differences in lipid profiles [Total cholesterol (TC), high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL), triglyceride (TG), non-high-density lipoprotein cholesterol (N-HDL) etc.] were analysed between the non-elderly and elderly AMI patients, in which a sub aged analysis was also performed.
Results Compared with the non-elderly group, the levels of TC, LDL, TG, TC/HDL, LDL/HDL, TG/HDL, N-HDL, apolipoprotein B were lower in the elder, while in which HDL, lipoprotein (a), and apolipoprotein A were higher. Female AMI patients were with higher levels of TC, LDL, HDL, N-HDL, apolipoprotein A and apolipoprotein B than the male in 60 to 69 year-old group. In the 70 to 79-year-old patients with AMI, TC, TG, HDL, N- HDL and apolipoprotein A were higher in the female than those in the male. Higher levels of TC, N-HDL, and apolipoprotein A were also observed in the female in the 80-year-old group. Comparison of lipid levels in the elderly with the same sex in different age groups showed TC, LDL, TG and N-HDL in the 60–69-year-old age group were higher than those in the 70–79 and ≥ 80 year-old age groups, without difference in HDL among the three groups. The lipid levels in the same sex are comparable between 70 to 79-year-old group and ≥ 80-year-old group. The ratio of AMI patients with normal lipid was significantly higher in the elderly than the non-elderly (34.89% vs. 20.21%). Isolated low HDL accounted for the largest proportion of combined lipid abnormalities in patients with AMI.
Conclusions Dyslipidemia in Chinese elderly patients with AMI was less serious than the non-elderly patients. In all age groups of elderly AMI, women had more severe dyslipidemia than men. Dyslipidemia was more serious in the younger old than that in the older old. Isolated low HDL was the most common combined lipid abnormality for both elderly and non-elderly patients with AMI.