Article Text

ASSA13-16-6 The Increased Circulatory RAS Activity Can Be Inhibited by Statins
  1. Su Hai,
  2. Hu Weitong,
  3. Peng Qiang,
  4. Hong Dezhi,
  5. Ma Jianyong,
  6. Yang Qing,
  7. Cheng Xiaoshu
  1. Department of Cardiology, Second Affiliated Hospital of NanchangUniversity


Objective To investigate the profile of circulatory renin-angiotensin system (RAS) activity in hypercholesterolemia (HC) patients treated with statins.

Methods This study included 18 primary HC patients and 18 sex-and age-matched healthy adults. Total cholesterol (TC), triglyceride (TG), LDL-C and blood glucose, angiotensin-converting enzyme (ACE) activity and angiotensin II (AngII) levels were measured at baseline. These parameters were measured again at 4 and 8 weeks after statin treatment in HC group respectively.

Results At baseline, the TC, TG and LDL-C, as well as ACE activity and AngII level, were significantly higher in HC group. On the baseline data of 36 participates, significant positive correlations existed between ACE activity and TC(r = 0.54) or LDL-C(r = 0.51), and between AngII level and TC(r = 0.34) or LDL-C(r = 0.27). In HC patients, 8 weeks statin treatment significantly decreased TC, LDL-C, as well as Ang II (35.46 ± 14.49 vs 71.10 ± 20.47 pg/ml, P < 0.05) levels and ACE activity (108.9 ± 51.9vs 180.1 ± 71.3 U/L, P < 0.05), meanwhile, positive correlations between RAS activity and TC or LDL-C levels measured before and after treatment were seen in HC patients.

Conclusions Serum cholesterol-lowering with statins is associated with decreasing circulatory RAS activity in hypercholesterolemia patients.

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