Objective The ischemia can induce flow-mediated dilatation (FMD), it is unclear that whether the ischemia induces decline on blood pressure (BP) and inter arm BP difference (IAD), and is there a correlation between FMD and IAD.
Methods This study enrolled 108 subjects. The bilateral BPs were simultaneously measured with two automatic BP measurement devices. The right brachial artery diameter (D) was measured by ultrasound technique. After the baseline diameter (D0) and BP (BP0) taking, the right brachial artery was occluded by cuff inflation for 5 minutes. Then the diameter was repeatedly measured 1(D1), 1.5 (D1.5) and 2 (D2) min, and the bilateral BPs were measured for 3times at 3 (BP3), 4 (BP4) and 5 (BP5) min after release of the occlusive cuff. The average of 3 ΔD values was recorded as post-ΔD, and the ratio of post-ΔD/D0 was calculated. The BP differences between left and right arms (BPl-r) at 4 time points were calculated respectively and the average of 3 post-ischemic BPl-r was recorded as post- BP l-r.
Results At baseline, the inter-arm SBP or inter-arm DBP were similar. Right arm ischemia induced significant DBP decline in the right arm only (69.0 ± 12.5 vs 72.7 ± 11.9 mmHg, p < 0.05) and significantly increased DBPl-r (–0.16 ± 2.16 vs –3.81 ± 3.2 mmHg, p < 0.05). A negative correlation was seen between ΔD/D0% and post- DBPl-r (r = 0.74, p < 0.05).
Conclusions The post-ischemic inter-arm DBP difference may be a potential index for clinical evaluation of vascular endothelial function.