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GW24-e0047 Gender Difference in Lipoprotein-Associated Phospholipase A2 Activity and Its Association with Cardiovascular Risk Factors
  1. Jia Zhangrong,
  2. Zhao Dong,
  3. Wang Wei,
  4. Qi Yue,
  5. Wang Miao,
  6. Liu Jun,
  7. Qin Lan-ping,
  8. Xie Wu-xiang,
  9. Zhao Fan,
  10. Liu Jing
  1. Beijing An Zhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases

Abstract

Objectives Lipoprotein-associated phospholipase A2(Lp-PLA2), a proinflammatory enzyme secreted primarily by macrophages, has been shown to be a predictor and potential therapeutic target of cardiovascular disease. The level and distribution of Lp-PLA2 and its associated factors are still unknown for Chinese population. Therefore, we aimed to study the level of Lp-PLA2 activity in men and women in a general population, and to investigate the association of Lp-PLA2 with known cardiovascular risk factors.

Methods A total of 1471 participants aged 45-74 were recruited from a cohort study in Beijing. Lp-PLA2 activity was determined by a colorimetric assay kit (Cayman Chemical, Ann Arbour, USA). Lp-PLA2 activity level and the correlation between Lp-PLA2 activityand risk factors were analysed in men and women.

Results 1. Lp-PLA2 activity was higher in males than in females (22.73 ± 8.52 nmol·min-1·ml-1 vs. 20.01 ± 8.06 nmol·min-1·ml-1, P < 0.001). 2. Age, waist circumference, systolic blood pressure, diastolic blood pressure and the prevalence of hypertension were higher in males than in females, while total cholesterol, low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) were higher in females than in males. 3. Lp-PLA2 activity was significantly correlated with lipids (LDL-C, total cholesterol, triglyceride, and HDL-C), blood pressure (systolic blood pressure and diastolic blood pressure), and adiposity associated parameters (waist circumference and BMI) in males; it was significantly correlated with lipid level (LDL-C, total cholesterol, triglyceride, and HDL-C) and age in females, while its correlation with variables associated with obesity or blood pressure were much weaker than those in males. 4. After adjustment for age, waist circumference, LDL-C, HDL-C, triglyceride, systolic blood pressure, glucose and high sensitivity C-reactive protein by Logistic regression model, Lp-PLA2 activity was still significantly higher in males than in females (OR = 1.72, 95% confidence interval = 1.34-2.21).

Conclusions The level of Lp-PLA2 activity and its association with known cardiovascular risk factors differed in males and females. The gender difference in Lp-PLA2 activity cannot be fully explained by known cardiovascular risk factors.

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