Objectives To investigate the correlation of resistin and endothelial function among preclinical Tibetan male young adults.
Methods All participants were recruited through young adults between 30 to 40-year-old with male gender in Lhasa city. All subjects were native Tibetan. Totally 90 healthy subjects were accepted after excluding hypertension, diabetes, hyperlipidemia, or other diagnosed atherosclerotic disease. The subjects were divided into 3 groups according to flow-mediated dilation (FMD): lower FMD (group A), intermediate FMD (group B), and higher FMD (group C). Body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), and cigarette smoking were evaluated. Venous blood was sampled for the measurement of lipid profile, fasting blood glucose (FBG), fasting insulin (FINS), endothelin-1 (ET-1) and plasma resistin quantitation. The noninvasive vascular endothelial function was evaluated through the measurement of FMD with B-mode ultrasound. The insulin resistance was estimated as HOMA-IR = FINS (mu/L)*FBG (mmol/L)/22.5.
Results No statistical significance was found between groups in age, smoke, SBP, DBP, fasting insulin, total cholesterol, and HOMA-IR (P > 0.05). In the lipid profile, HDL cholesterol in group C was better than that in group A and B (P < 0.01). Also, LDL cholesterol in group C was lower than that in group A and B (P < 0.01). Triglyceride in group C was lower than in group B (P < 0.05), but all subjects in 3 groups had normal triglyceride levels. BMI, which is an indicator for obesity, was much lower in group C than in group A and B (P < 0.05 and 0.01 respectively). Comparison of plasma resistin concentrations: group A > group B > group C (P < 0.01). Comparison of plasma ET-1 concentrations had the similar result: group A > group B > group C (P < 0.05). The multivariate regression analysis showed that total cholesterol (P < 0.05), LDL cholesterol (P < 0.01), and plasma resistin (P < 0.01), plasma ET-1 (P < 0.01) were correlated with FMD.
Conclusions Resistin involved in endothelial dysfunction in preclinical male young Tibetan adults.