Objectives To investigate the correlation between serum uric acid (UA) and carotid intima-media thickness (IMT) and the effect of statin therapy in Tibetan patients with hyperurieemia and dyslipidemia.
Methods All participants received 20 mg/d atorvastatin in a single nocturnal dose for 1-2 weeks. The levels of uric acid (UA), total cholesterol (TC), triglyeeride (TG), high density lipoprotein cholesterol (HDL-C), 1ow density lipoprotein cholesterol (LDL-C), blood urea nitrogen (BUN), creatinine (Cr), amlnotransferase were measured at baseline and 12 weeks after treatment.
Results A total of 80 patients with abnormal baseline level of serum TC and uric acid were assigned to this study. In multivariable regression analysis, baseline TC, TG, LDL, HDL, and UA levels correlated with IMT value (P < 0.05). Atorvastatin reduced TC level by 33.8%, TG by 24.9%, LDL by 12.2%. Serum UA level significantly lowered after statin treatment (by 12.6%; P < 0.01).
Conclusions Hyperuricemia is strongly correlated with carotid IMT. Atorvastatin has favourable effects on lipid regulation and UA lowering.