Objectives To explore the value of serum uric acid (SUA) level with essential hypertension in predicting the occurrence of coronary heart disease (CHD).
Methods 546 patients with chest pain undergoing coronary angiography were enrolled. Base on the condition of whether CHD or not, patients divided into essential hypertension only group (n = 259) and essential hypertension combined with CHD group. To analysis whether there is a correlation between SUA levels in hypertensive patients and Coronary heart disease risk factors and it with the incidence of coronary heart disease.
Results There is a significant difference in Statistically when those two groups compare in the level SUA and serum creatinine, glucose, triglyceride, total cholesterol, low density lipoprotein cholesterol and high density lipoprotein cholesterol (P < 0.01). Logistic regression analysis showed that age (OR = 1.17), coronary artery score (OR = 1.29), serum uric acid (SUA) (OR = 1.30) and high density lipoprotein cholesterol (HDLC) (OR = 1.50) is risk factors of hypertension with coronary heart disease. Linear correlation analysis showed that there is a linear correlation between hypertensive patients with coronary artery disease and coronary artery score SUA levels (r = 0.18, P < 0.01).
Conclusions Hyperuricemia is a independent predictor in the primary hypertension with coronary heart disease.