Objectives Objective Sensitive clinical evaluation items for detecting the early stages of PD could improve development of new treatments. The aim of this study was to analyse on clinical evaluation of parkinson’s disease with integrated traditional chinese and western medicine therapy.
Methods A randomised controlled trial with double-blind in various therapeutic centres was applied on the patients, who were randomly divided into the trial group and the control group. The patients in control group were treated with placebo, meanwhile, the patients in treatment group were given Bushen Huoxue Granule (BHG). Both groups based on Madopar treatment. The treatment effects were assessed at every month during the 9 months’ treatment. The clinical evaluation items included UPDRS score, sleep scale score,10 m turned back test and timed motor test. The above outcome assessment items were considered as dependent variable, Age, Sex, Duration of PD, H-Y and Madopar of admitted PD patients were considered as independent variable, as well.
Results We established the multiple linear regression mode to analyse the effects after analysis of repeated measurement data in the study. Results H-Y showed significant effects on UPDRS‖ score, UPDRSIII score, getting up time (P<0.01), Madopar and H-Y had effects on 10m×2 time (P<0.05), Madopar on sleep scale score (P<0.05), age on JST-left (P<0.01) and age, duration of PD on JST-right (P<0.05). Conclusions The six items (UPDRSII score, UPDRSIII score, Sleep scale score, Gettingup time, 10m×2 time, Turning time) have high sensibility to all PD patients. There is a correlation between H-Y, Madopar and clinical evaluation items for PD treatment.
Conclusions The JST-left and JST-right cannot considered as sensitive items to PD clinical evaluation because of many influencing factors.
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.