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GW24-e0505 Direct comparison of SW-CG-HYPR and conventional SR-Turbo-FLASH myocardial perfusion MRI for detection of coronary artery disease
  1. Yang Jun1,
  2. Heng Ma1,
  3. Yanyan Jing1,
  4. Jing Liu1,
  5. Lan Ge2,
  6. Debiao Li2
  1. 1Yuhuangding Hospital, Yantai, Shandong Province, China
  2. 2University of California, Los Angeles, CA, USA

Abstract

Objectives Sliding-window conjugate-gradient highly constrained back-projection reconstruction (SW-CG-HYPR) myocardial perfusion MRI allows increased spatial coverage, improved temporal and spatial resolution and signal-to-noise ratio compared with the conventional SR-Turbo-FLASH. The diagnostic accuracy of myocardial perfusion MRI with SW-CG-HYPR for detecting coronary artery disease (CAD) has not been directly compared to that with conventional SR-Turbo-FLASH. The purpose of the work was to prospectively compare the diagnostic value of SW-CG-HYPR and conventional SR-Turbo-FLASH for myocardial perfusion MRI in patients with suspected CAD.

Methods Thirtyconsecutivepatients with suspected CAD who were scheduled for coronary angiography underwent myocardial perfusion MRI with both SW-CG-HYPR and SR-Turbo-FLASH in random order at 3.0 T. Perfusion defects were interpreted visually by 2 blinded observers and were correlated to x-ray angiographic stenoses ≥ 50%. Receiver-operating characteristic (ROC) curve analysis was used to compare the diagnostic performance of the two imaging techniques.

Results In the per-patient analysis, SW-CG-HYPR provided a higher sensitivity (94% vs. 89%), specificity (83% vs. 75%) and diagnostic accuracy (90% vs. 83%) for detection of CAD than SR-Turbo-FLASH. In the per-vessel analysis, the diagnostic performance of SW-CG-HYPR was significantly greater than that of SR-Turbo-FLASH for the overall detection of CAD (area under ROC curve: 0.96 ± 0.02 vs. 0.90 ± 0.03, respectively; p < 0.05).

Conclusions SW-CG-HYPR myocardial perfusion MRI has higher diagnostic accuracy than conventional SR-Turbo-FLASH for detection CAD.

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