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GW24-e2998 Retinol-binding protein 4 as a novel cardiovascular disease risk factor in patients with coronary artery disease and hyperinsulinemia
  1. Li Fei1,
  2. Tianlun Yang1
  1. 1Department of Cardiology, Xiangya Hospital, Central South University, Changsha 410078, China
  2. 2Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi’an 710032 China


Objectives Retinol-binding protein 4 (RBP4) is an adipokine associated with insulin resistance (IR) and obesity-related metabolic disorders. We compared RBP4 levels between coronary artery disease (CAD) patients and controls to evaluate its association with cardiovascular risk factors.

Methods Sixty patients with coronary angiography-confirmed CAD (including 30 patients with CAD and hyperinsulinemia (CAD/HIns group)) and 29 healthy subjects were enrolled. Serum RBP4, insulin resistance indexes and cardiovascular risk factors were assessed in these subjects.

Results Serum RBP4 levels in the CAD/HIns group were higher than in the CAD and control groups (P < 0.01). RBP4 level were significantly associated with cardiovascular risk factors, such as body mass index (BMI), triglycerides (TG), high density lipoprotein cholesterol (HDL-C), uric acid (UA), high sensitivity C reactive protein (hsCRP) and adiponectin (APN) (P < 0.01). Two-hour postprandial insulin (2hPIns), homeostatic model assessment of insulin resistance (HOMA-IR) and APN were independent factors associated with RBP4 (r = 0.224, r = 0.456, r = 0.294, P < 0.01).

Conclusions The present study shows that RBP4 is associated with cardiovascular risk factors related to insulin resistance and CAD. Circulating RBP4 could be a marker of metabolic complications and atherosclerosis and could be used to assess CAD.

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