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GW24-e1018 Association of chronic kidney dysfunction with the complexity of coronary artery disease
  1. Yan Liqiu,
  2. Guo Nan,
  3. Zheng Ye,
  4. Han Jia,
  5. Han Lixian,
  6. Cao Xufen
  1. Cangzhou Central Hospital, Hebei Medical University

Abstract

Objectives To investigate the association of chronic kidney dysfunction with the complexity of coronary artery disease.

Methods We prospectively included 1380 consecutive patients who underwent coronary angiography for the first time in our hospital and were angiographically diagnosed with coronary artery disease from January 2011 to June 2012. The complexity of coronary artery disease were classified according to the American College of Cardiology/American Heart Association (ACC/AHA) grading system as types A, B1, B2, and C. Estimated glomerular filtration rate (eGFR) was calculated by the simplified Modification of Diet in Renal Disease (MDRD) equation. Patients were classified into 3 stages according to eGFR as follows: normal renal function (n = 234, eGFR ≥ 90 ml/min/1.73 m2), mild renal dysfunction (n = 881, 60 ≤ eGFR<90 ml/min/1.73 m2) and moderate or severe renal dysfunction (n = 265, eGFR <60 ml/min/1.73 m2). Ordinal logistic regression was used to analyse the association of chronic kidney dysfunction with the complexity of coronary artery disease.

Results Patients with mild, moderate or severe renal dysfunction were older (F = 56.82, P < 0.001), more often female (χ 2 = 66.29, P < 0.001) and more likely to have a history of hypertension (χ 2 = 17.57, P < 0.001), diabetes (χ 2 = 20.97, P < 0.001) and hyperlipidemia (χ 2 = 10.48, P = 0.005) than those with normal renal function (P < 0.001). The percentage of lesions of types B2 or C in moderate or severe renal dysfunction group was higher than that in normal renal function group (χ 2 = 175.03, P < 0.001). The ordinal logistic regression showed that age, male, hypertension, diabetes, C-reactive protein and eGFR were independent risk factors of the ACC/AHA lesion classification.

Conclusions Age, male, hypertension, diabetes, C-reactive protein and eGFR were independent risk factors of the complexity of coronary artery disease.

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