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GW24-e3083 Association of increased carotid intima-media thickness and plaque score with higher SYNTAX score
  1. N Rama Kumari1,
  2. I. Bhaskara Raju1,
  3. M Aruna Devi2,
  4. R C Mishra2,
  5. M Praveen1
  1. 1Gandhi Medical College
  2. 2Nims

Abstract

Objectives The present study was undertaken to determine the relationship between carotid-US findings and severity of the SYNTAX score (SX score).

Methods A total of 302 consecutive patients who underwent carotid-US and first coronary angiography were included. Carotid-US was used to determine the mean common carotid artery intima-media thickness (meanIMT) and the plaque score (PS). The prevalence of low (0–22), intermediate (23–32) and high (≥ 33) SX score patients were 47%, 22% and 4.3% respectively. Mean CIMT, Plaque Score and the overall SYNTAX score (SX score) were 0.96 ± 0.50, 6.7 ± 10.3 and 20 ± 14.6 respectively. In univariate analysis, there was a significant correlation between the overall SX score and CIMT (r = 0.18 p < 0.0001), Plaque Score (r = 020 p < 0.000), hypertension (r = 0.1, p < 0.09), HDLC Cholesterol (r = 0.18, p < 0.002). In Bivariate analysis, CIMT(β = 0.006 p < 0.001) Plaque Score (β = 0.14 P < 0.000), were independently associated with SX score. In ROC Curve the best cut off value of a mean IMT of 0.9 mm, the sensitivity was 65% and Specificity was 60%, for intermediate/high SYNTAX score. Similarly, a cut off level of a Plaque Score of 3 presented a sensitivity of 70%, and Specificity was 60%. A mean IMT ≥0.9 mm and a PS ≥ 3 had negative predictive values of 46 and 47.4%, respectively, for intermediate/high SX score.

Results A total of 302 consecutive patients who underwent carotid-US and first coronary angiography were included. Carotid-US was used to determine the mean common carotid artery intima-media thickness (meanIMT) and the plaque score (PS). The prevalence of low (0–22), intermediate (23–32) and high (≥ 33) SX score patients were 47%, 22% and 4.3% respectively. Mean CIMT, Plaque Score and the overall SYNTAX score (SX score) were 0.96 ± 0.50, 6.7 ± 10.3 and 20 ± 14.6 respectively. In univariate analysis, there was a significant correlation between the overall SXscore and CIMT (r = 0.18 p < 0.0001.), Plaque Score (r = 020 p < 0.000), hypertension (r = 0.1, p < 0.09), HDLC Cholesterol (r = 0.18, p < 0.002.). In Bivariate analysis, CIMT(β = 0.006 p < 0.001) Plaque Score (β = 0.14 P < 0.000), were independently associated with SX score. In ROC Curve the best cut off value of a mean IMT of 0.9 mm, the sensitivity was 65% and Specificity was 60%, for intermediate/high SYNTAX score. Similarly, a cut off level of a Plaque Score of 3 presented a sensitivity of 70%, and Specificity was 60%. A mean IMT ≥ 0.9 mm and a PS ≥ 3 had negative predictive values of 46 and 47.4%, respectively, for intermediate/high SX score.

Conclusions Carotid-US parameters have predictive value for the SX score.

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