Objectives Investigate the difference of inhibiting intima proliferation between telmisartan, valsartan and sirolimus eluting stent.
Methods Telmisartan eluting stent (TES), valsartan eluting stent (VES), sirolimus eluting stent (SES) and polymer eluting stent (PES) were randomised to be implanted in twenty experimental swines. All the swines were sacrificed at the end of 1st month and 3rd month, respectively. After they were sacrificed, took out the coronary artery and use the method of Western blot to detect Type I, type III collagen, AT1 and AT2 receptor protein expression. Type I, type III collagen, AT1 and AT2 receptor mRNA expression was measured by Real-Time PCR.
Results 1, After one month and three months, the polymer eluting stent (PES) group neointimal thickness compared with the other three groups (P < 0.05), sirolimus eluting stent (SES) group neointimal thickness significantly less than telmisartan eluting stent (TES) and valsartan eluting stent (VES) group (P < 0.05), but the valsartan coating group is no significant statistical difference with telmisartan coating group (P> 0.05).
2, After one month and three months, TES and VES groups inhibit the AT1 receptor, and promote the AT2 receptor mRNA expression and protein expression are stronger than SES group, the difference are statistically significant; while TES group has stronger effect on the AT2 receptor mRNA expression than VES group. after 3 months, TES group has a stronger role of the AT1 receptor inhibition than VES group.
3, After one month, SES group compared with the other three groups in the inhibition of type I, III collagen mRNA has significant difference (P < 0.05), while TES group has no significant difference with VES group; After three months, TES group has stronger effect on inhibition of type III collagen mRNA expression than VES and SES group, the expression of type I collagen mRNA was no advantage, however I, III collagen expression levels after 3 months among three groups show no significant difference.
Conclusions 1, TES and VES compared with SES have stronger role on inhibiting the expression of AT1 and up regulating AT2 receptor expression, meanwhile, telmisartan could enhance the expression of AT2 receptor mRNA than valsartan.
2, TES has stronger inhibition of type III collagen mRNA expression.
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