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GW24-e1174 The related mechanism research of adenosine protection to myocardium
  1. Wei Guo,
  2. Hui Chen
  1. Beijing Friendship Hospital, Capital Medical University

Abstract

Objectives To discusses the possible related mechanism of acute coronary syndrome (ACS) patients undergoing non-urgent percutaneous coronary interention (PCI) in application of adenosine.

Methods We enrolled 156 consecutive patients with acute coronary syndrome who were scheduled for elective percutaneous coronary intervention. Patients were randomised into group A(adenosine 50 ug, n = 78),group B(control saline, n = 78), we determine NO, SOD and MDA concentrations or activity in the blood sample before and 1h, 12h, 24h after PCI to analyse the changes within the same group at different times, and between different groups were used to assess myocardial necrosis before and 1h, 12h, 24h after PCI. To study the possible protective mechanism of adenosine played in myocardial ischaemia reperfusion injury.

Results No significant differences were observed bewteen the two groups with regard to baseline and angiographic characteristics. The concentration of plasma NO change in the group comparison: the concentration of plasma NO in control group at each time point no significant changes, The difference was not statistically significant (P > 0.05); Adenosine group NO in postoperative 1, 12, 24 h has an Significant rise than preoperative (P < 0.05), But the postoperative 1, 12, 24 h no significant difference (P > 0.05). NO change in plasma concentration is compared between groups: Adenosine group and control group plasma NO levels in the preoperative no significant difference (P > 0.05); In postoperative 1, 12, 24 h has an Significant rise than control group (P < 0.05). The concentration of plasma SOD change in the group comparison: the concentration of plasma SOD in control group at each time point no significant changes, The difference was not statistically significant (P > 0.05); Adenosine group SOD in postoperative 1, 12, 24 h has an Significant rise than preoperative (P < 0.05), But the postoperative 1, 12, 24 h no significant difference (P > 0.05). SOD change in plasma concentration is compared between groups: Adenosine group and control group plasma SOD levels in the preoperative no significant difference (P > 0.05); In postoperative 1, 12, 24 h has an Significant rise than control group (P < 0.05). The concentration of plasma MDA change in the group comparison: control group MDA in postoperative 1, 12, 24 h has an Significant rise than preoperative (P < 0.05), But the postoperative 1, 12, 24 h no significant difference (P > 0.05). The concentration of plasma NO in adenosine group at each time point no significant changes, the difference was not statistically significant (P > 0.05); MDA change in plasma concentration is compared between groups: control group and Adenosine group plasma MDA levels in the preoperative no significant difference (P > 0.05); In postoperative 1, 12, 24 h has an Significant rise than Adenosine group (P < 0.05).

Conclusions Coronary artery injection in small doses adenosine. Through the comparison, among the concentration of NO, MDA and SOD vigor between adenosine group and control group, it reveal that Adenosine play a role to protect myocardium, reduce the reperfusion injury may be relate to the mechanism that can promote the concentration of NO, and SOD, Inhibit the production of oxygen free radical, Reduce the lipid peroxide.

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